Description

trans-Chalcone-D12, 98 Atom % D is a deuterated analog of the natural product chalcone, where twelve hydrogen atoms are replaced with deuterium, achieving a high isotopic enrichment of 98 atom %. This high level of deuteration makes it an invaluable internal standard and tracer in quantitative mass spectrometry and NMR studies, ensuring superior accuracy and reliability in analytical workflows. It is primarily utilized by researchers and manufacturers in pharmaceutical development, metabolic research, and analytical chemistry for precise quantification and mechanistic studies. The compound is supplied with a Certificate of Analysis detailing its isotopic purity and chemical specifications.

Application

• Internal Standard for LC-MS/MS: Used as a high-purity, stable isotope-labeled internal standard for the accurate quantification of chalcone and its derivatives in complex biological matrices.
• Metabolic Pathway Tracing: Serves as a deuterium-labeled tracer in pharmacokinetic and drug metabolism studies to investigate absorption, distribution, metabolism, and excretion (ADME) profiles.
• NMR Spectroscopy: Employed as a probe in nuclear magnetic resonance (NMR) spectroscopy to study molecular structure, dynamics, and interactions without signal interference from protonated species.
• Pharmaceutical Reference Material: Acts as a certified reference material (CRM) for quality control and method validation in the development of chalcone-based therapeutic agents.
• Chemical Synthesis Intermediate: Used in the synthesis of more complex deuterated compounds for research in medicinal chemistry and material science.

Basic Information

Product Name	trans-Chalcone-D12, 98 Atom % D
CAS No.	307496-21-5
Molecular Formula	C15D12O
Molecular Weight	224.33 g/mol
Synonyms	(E)-1,3-Diphenyl-2-propen-1-one-D12; 1,3-Diphenyl-2-propen-1-one-D12; Chalcone-D12; Benzylideneacetophenone-D12; (E)-Chalcone-D12; 3-Phenyl-1-(phenyl-D5)-2-propen-1-one-D7; Deuterochalcone; Perdeuterated trans-Chalcone
EINECS	Contact for details

Quality Control

Every batch of trans-Chalcone-D12, 98 Atom % D is manufactured and analyzed under strict quality management protocols. The product undergoes rigorous testing to confirm its chemical identity, isotopic purity (minimum 98 atom % D), and chemical purity. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results from NMR, HPLC, and mass spectrometry analyses. Our quality system ensures traceability and compliance with relevant standards for research and reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Atom % D)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.