Description

3-[1-(3,5-Difluorobenzyl)-1H-Indol-3-Yl]Acrylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its unique indole-acrylic acid structure with fluorinated benzyl substitution. This compound matters for its critical role as a key building block in the synthesis of novel, potent small-molecule therapeutics, particularly within kinase inhibitor research. Pharmaceutical R&D teams and fine chemical manufacturers need it to develop next-generation drug candidates targeting a range of oncological and inflammatory diseases, where its specific molecular architecture is essential for achieving desired biological activity and selectivity.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of targeted kinase inhibitors and other biologically active molecules.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities for drug discovery programs.
• Biochemical Tool Compound: Employed in the development of assay probes and inhibitors for studying specific enzymatic pathways in academic and industrial research settings.
• Custom Synthesis & Contract Manufacturing: A key starting material for CDMOs (Contract Development and Manufacturing Organizations) producing APIs (Active Pharmaceutical Ingredients) for clinical trials.
• Preclinical Development: Utilized in the scale-up synthesis of candidate drugs for pharmacological and toxicological evaluation.

Basic Information

Product Name	3-[1-(3,5-Difluorobenzyl)-1H-Indol-3-Yl]Acrylic Acid
CAS No.	307352-81-4
Molecular Formula	C19H13F2NO2
Molecular Weight	325.31 g/mol
Synonyms	3-[1-[(3,5-Difluorophenyl)methyl]-1H-indol-3-yl]-2-propenoic acid; (E)-3-(1-(3,5-Difluorobenzyl)-1H-indol-3-yl)acrylic acid; 3-(1-(3,5-Difluorobenzyl)-1H-indol-3-yl)prop-2-enoic acid; 307352-81-4; 1H-Indole-3-acrylic acid, 1-[(3,5-difluorophenyl)methyl]-; DFB-Indole Acrylic Acid
EINECS	Contact for details

Quality Control

Our 3-[1-(1-(3,5-Difluorobenzyl)-1H-Indol-3-Yl]Acrylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.