Description

Methyl 3-(Chlorosulfonyl)-4-Phenyl-5-(Trifluoromethyl)Thiophene-2-Carboxylate is a high-value, multi-functional chemical intermediate characterized by its reactive chlorosulfonyl group and trifluoromethyl-substituted thiophene core. This compound matters for its critical role as a versatile building block in advanced organic synthesis, enabling the introduction of key pharmacophores and functional groups. It is primarily needed by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Research: Acts as a monomer or functionalization agent for creating specialty polymers and advanced organic electronic materials.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and labeled compounds for biochemical and diagnostic research.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	Methyl 3-(Chlorosulfonyl)-4-Phenyl-5-(Trifluoromethyl)Thiophene-2-Carboxylate
CAS No.	306935-98-8
Molecular Formula	C13H8ClF3O4S2
Molecular Weight	384.78 g/mol
Synonyms	Methyl 3-(chlorosulfonyl)-4-phenyl-5-(trifluoromethyl)thiophene-2-carboxylate; 3-(Chlorosulfonyl)-4-phenyl-5-(trifluoromethyl)thiophene-2-carboxylic acid methyl ester; 2-Thiophenecarboxylic acid, 3-(chlorosulfonyl)-4-phenyl-5-(trifluoromethyl)-, methyl ester; Methyl 4-phenyl-3-sulfonylchloride-5-trifluoromethylthiophene-2-carboxylate
EINECS	Contact for details

Quality Control

Our Methyl 3-(Chlorosulfonyl)-4-Phenyl-5-(Trifluoromethyl)Thiophene-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids, bases, and oxidizing agents. Due to the reactive chlorosulfonyl group, ensure containers are kept tightly sealed under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.