Description

3-(Thiazol-2-Ylcarbonyl)-1,1,1-Trifluoroacetone is a high-value, specialized fluorinated building block containing both a thiazole and a trifluoroacetyl moiety. This compound matters for its unique reactivity profile, enabling the synthesis of complex molecules with enhanced properties like metabolic stability and lipophilicity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for kinase inhibitors and antimicrobial agents.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and pesticides that require fluorine atoms for improved efficacy and environmental profile.
• Material Science Research: Serves as a precursor for fluorinated heterocyclic compounds used in organic electronics and specialty polymers.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and labeled compounds for biochemical assays.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring the introduction of a thiazole-trifluoromethyl ketone functionality.

Basic Information

Product Name	3-(Thiazol-2-Ylcarbonyl)-1,1,1-Trifluoroacetone
CAS No.	306935-40-0
Molecular Formula	C7H4F3NO2S
Molecular Weight	223.17 g/mol
Synonyms	1,1,1-Trifluoro-3-(2-thiazolylcarbonyl)acetone; 3-(2-Thiazolylcarbonyl)-1,1,1-trifluoroacetone; 2-Thiazolecarboxylic acid, 2-acetyl-1,1,1-trifluoro-3-oxopropyl ester; 3-Oxo-4-(thiazol-2-yl)-1,1,1-trifluorobutan-2-one; TFTA; Thiazolyl trifluoroacetone
EINECS	Contact for details

Quality Control

Every batch of 3-(Thiazol-2-Ylcarbonyl)-1,1,1-Trifluoroacetone is produced and tested under a strict quality management system. We ensure high purity and consistency suitable for demanding research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and GC-MS is provided with each shipment to guarantee supply reliability and technical compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.