Description

3-(4-Hydroxyphenyl)-5-(2-Thienylmethylene)-2-Thioxo-1,3-Thiazolidin-4-One is a specialized heterocyclic organic compound featuring a thiazolidinone core, a hydroxyphenyl group, and a thienylmethylene substituent, making it a valuable synthetic intermediate. This compound is of significant interest for its potential as a pharmacophore in medicinal chemistry research and development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors seeking novel bioactive molecules.

Application

• Pharmaceutical Intermediate: Serves as a key building block for the synthesis of novel drug candidates, particularly those targeting metabolic disorders, inflammation, or infectious diseases.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity of lead compounds.
• Agrochemical Development: Investigated as a precursor for creating new active ingredients in herbicides, fungicides, or insecticides.
• Chemical Biology Probes: Employed in the development of molecular probes to study enzyme function or cellular pathways.
• Material Science: Potential monomer or additive for creating polymers with specific electronic or optical properties.
• Academic & Institutional R&D: Used in universities and research institutes for exploratory synthetic chemistry and novel heterocycle development.

Basic Information

Product Name	3-(4-Hydroxyphenyl)-5-(2-Thienylmethylene)-2-Thioxo-1,3-Thiazolidin-4-One
CAS No.	306323-46-6
Molecular Formula	C14H9NO2S2
Molecular Weight	295.36 g/mol
Synonyms	5-[(2-Thienyl)methylene]-3-(4-hydroxyphenyl)-2-thioxo-4-thiazolidinone; 3-(4-Hydroxyphenyl)-5-(thiophen-2-ylmethylene)-2-thioxothiazolidin-4-one; 4-Thiazolidinone, 3-(4-hydroxyphenyl)-5-[(2-thienyl)methylene]-2-thioxo-; RHOD-5; A potential PPARγ agonist intermediate; Thiazolidinedione derivative
EINECS	Contact for details

Quality Control

Our 3-(4-Hydroxyphenyl)-5-(2-Thienylmethylene)-2-Thioxo-1,3-Thiazolidin-4-One is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.