Description

Ethyl (E)-2-(2-Cyano-3-(3-Nitrophenyl)Acrylamido)-4,5,6,7-Tetrahydrobenzo[B]Thiophene-3-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is of significant value for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is primarily needed by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in developing new drug candidates, especially within oncology and central nervous system (CNS) research.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Organic Synthesis Building Block: Used in research and development for constructing complex heterocyclic compounds, leveraging its tetrahydrobenzo[b]thiophene and acrylamido functional groups.
• Medicinal Chemistry Research: Serves as a scaffold for structure-activity relationship (SAR) studies to optimize biological activity and pharmacokinetic properties.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for exploring new synthetic methodologies and reaction pathways involving nitrophenyl and cyanoacrylate motifs.

Basic Information

Product Name	Ethyl (E)-2-(2-Cyano-3-(3-Nitrophenyl)Acrylamido)-4,5,6,7-Tetrahydrobenzo[B]Thiophene-3-Carboxylate
CAS No.	305375-06-8
Molecular Formula	C23H21N3O5S
Molecular Weight	451.50 g/mol
Synonyms	Ethyl (2E)-2-[(2Z)-2-cyano-3-(3-nitrophenyl)prop-2-enamido]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate; 4,5,6,7-Tetrahydrobenzo[b]thiophene-3-carboxylic acid, 2-[(1Z)-2-cyano-1-(3-nitrophenyl)ethenyl]amino]-, ethyl ester; (E)-Ethyl 2-(2-cyano-3-(3-nitrophenyl)acrylamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate; CAS 305375-06-8; 305375-06-8; Acrylamide derivative, THBTC derivative.
EINECS	Contact for details

Quality Control

Our Ethyl (E)-2-(2-Cyano-3-(3-Nitrophenyl)Acrylamido)-4,5,6,7-Tetrahydrobenzo[B]Thiophene-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing purity (typically ≥95% by HPLC), identity confirmation, and impurity profiles are available upon request to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Maximum Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.