Description

n-Butylscopolammonium Bromide-D9 is a deuterated analog of the anticholinergic agent butylscopolamine, specifically labeled with nine deuterium atoms. This compound is of critical importance as a high-purity internal standard for quantitative mass spectrometry analysis in pharmaceutical research and bioanalytical studies. It is primarily needed by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in method development, pharmacokinetic studies, and drug metabolism research to ensure accurate and reliable quantification of the parent drug.

Application

• Primary use as a stable isotope-labeled internal standard for Liquid Chromatography-Mass Spectrometry (LC-MS) and LC-MS/MS bioanalysis.
• Essential for quantitative pharmacokinetic (PK) and pharmacodynamic (PD) studies of butylscopolamine (hyoscine butylbromide).
• Critical component in drug metabolism and disposition (DMPK) research to track analyte recovery and correct for ionization suppression/enhancement.
• Used in the development and validation of regulatory-compliant bioanalytical methods according to FDA and EMA guidelines.
• Application in clinical research for accurate measurement of drug concentrations in biological matrices (plasma, serum, urine).
• Supports high-quality research in pharmacology and toxicology studies requiring precise quantification.

Basic Information

Product Name	n-Butylscopolammonium Bromide-D9
CAS No.	305363-07-9
Molecular Formula	C21H21D9BrNO4
Molecular Weight	440.39 g/mol (for deuterated form)
Synonyms	Scopolamine Butylbromide-D9; Hyoscine Butylbromide-D9; Butylscopolamine Bromide-D9; N-Butylscopolammonium Bromide-D9; Buscopan-D9 (labeled analog); (1R,2R,4S,5S,7s)-9-Butyl-7-{[(2S)-3-hydroxy-2-phenylpropanoyl]oxy}-9-methyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide-D9; Deuterated Hyoscine N-Butylbromide
EINECS	Contact for details

Quality Control

Our deuterated internal standards are produced under strict quality control to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is characterized using advanced techniques including NMR (for deuterium incorporation), HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) is provided, detailing assay purity, isotopic enrichment, and solvent content, supporting compliance with GLP and GMP principles for research use.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. The product is light-sensitive (store away from light). For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.