Description

1-Amino-4-Fluoro-Indan-2-Ol is a high-purity fluorinated indane derivative, serving as a critical chiral building block in advanced organic synthesis. Its unique structure, featuring both amino and fluoro substituents on the indane scaffold, makes it a valuable intermediate for constructing complex molecules with specific biological activity. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Asymmetric Synthesis: Utilized as a building block in catalytic asymmetric reactions to introduce stereochemical complexity into target molecules.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in enantioselective transformations.
• Agrochemical Research: Employed in the synthesis of advanced intermediates for novel pesticides and herbicides, leveraging the biological activity of the fluoro-indane core.
• Material Science: Investigated as a monomer or functional additive for specialty polymers and advanced materials requiring specific optical or electronic properties.
• Academic & Contract Research: Supplied to universities and CROs (Contract Research Organizations) for fundamental chemical research and custom synthesis projects.

Basic Information

Product Name	1-Amino-4-Fluoro-Indan-2-Ol
CAS No.	303022-40-4
Molecular Formula	C9H10FNO
Molecular Weight	167.18 g/mol
Synonyms	4-Fluoro-1-aminoindan-2-ol; (1S,2R)-1-Amino-4-fluoro-2,3-dihydro-1H-inden-2-ol; (1R,2S)-1-Amino-4-fluoro-2,3-dihydro-1H-inden-2-ol; 1-Amino-4-fluoro-2,3-dihydro-1H-inden-2-ol; 4-Fluoro-2-hydroxy-1-indanamine; 1-Amino-4-fluoroindan-2-ol; AFIO; 1-AFI
EINECS	Contact for details

Quality Control

Our 1-Amino-4-Fluoro-Indan-2-Ol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to meet the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (enantiomer excess)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.