Description

2-[(tert-Butoxycarbonyl)Amino]-4-(Trifluoromethyl)-1,3-Thiazole-5-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a protected amino group and a trifluoromethyl-substituted thiazole core. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting metabolic and central nervous system disorders. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of protease inhibitors, kinase inhibitors, and other small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of complex drug candidates, especially those incorporating the trifluoromethyl group for enhanced metabolic stability and bioavailability.
• Protease Inhibitor Development: Used in the research and production of protease inhibitors, where the thiazole carboxylic acid moiety acts as a critical pharmacophore.
• Kinase Inhibitor Synthesis: Serves as a precursor in creating targeted kinase inhibitors for oncology and inflammatory disease applications.
• Peptidomimetic Chemistry: The Boc-protected amino acid structure makes it valuable for constructing peptidomimetic compounds in drug discovery.
• Agrochemical Research: Potential intermediate in the development of advanced agrochemicals, leveraging the biological activity of the thiazole ring.
• Material Science: Can be investigated as a monomer or functional additive for specialty polymers with unique electronic or surface properties.

Basic Information

Item	Details
Product Name	2-[(tert-Butoxycarbonyl)Amino]-4-(Trifluoromethyl)-1,3-Thiazole-5-Carboxylic Acid
CAS No.	302963-97-9
Molecular Formula	C10H11F3N2O4S
Molecular Weight	312.27 g/mol
Synonyms	Boc-4-(Trifluoromethyl)thiazole-5-carboxylic acid; 2-[(Boc)Amino]-4-(trifluoromethyl)-1,3-thiazole-5-carboxylic acid; 5-Thiazolecarboxylic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-4-(trifluoromethyl)-; 2-(tert-Butoxycarbonylamino)-4-trifluoromethylthiazole-5-carboxylic acid; N-Boc-4-(trifluoromethyl)thiazol-5-yl-carboxylic acid; 2-(Boc-amino)-4-(trifluoromethyl)thiazole-5-carboxylic acid; 302963-97-9
EINECS	Contact for details

Quality Control

Our 2-[(tert-Butoxycarbonyl)Amino]-4-(Trifluoromethyl)-1,3-Thiazole-5-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals to ensure compliance with pharmaceutical intermediate standards. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.