Description

Dde-L-Phe-Ol CAS NO 302916-36-5 is a specialized protected amino acid derivative, specifically the 1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)ethyl (Dde) derivative of L-phenylalaninol. This compound is a critical building block in solid-phase peptide synthesis (SPPS), valued for its orthogonal protecting group strategy. Its primary function is to enable the selective deprotection of side-chain amines under mild conditions, allowing for the sequential and controlled assembly of complex peptides. This makes it an essential reagent for researchers and manufacturers in pharmaceutical development, proteomics, and bioconjugation.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key intermediate for the controlled, sequential introduction of phenylalanine derivatives with orthogonal side-chain protection.
• Pharmaceutical Research & Development: Used in the synthesis of peptide-based drug candidates, hormones, and diagnostic agents.
• Bioconjugation and Labeling: Facilitates the site-specific attachment of fluorophores, tags, or other molecules to peptides for imaging and targeting studies.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive peptides.
• Academic & Industrial Research: A fundamental tool in biochemistry and molecular biology labs for studying protein-protein interactions and signal transduction.
• Production of Custom Peptides: Used by CROs and CDMOs for the reliable and scalable manufacture of therapeutic and research-grade peptides.

Basic Information

Product Name	Dde-L-Phe-Ol
CAS No.	302916-36-5
Molecular Formula	C19H25NO4
Molecular Weight	331.41 g/mol
Synonyms	1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)ethyl-L-phenylalaninol; Dde-Phe-ol; N-[(1E)-1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)ethyl]-L-phenylalaninol; Fmoc-Dde-Lys-OH derivative precursor; Orthogonal protecting group reagent; (2S)-2-[[(2E)-1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)ethyl]amino]-3-phenylpropan-1-ol
EINECS	Contact for details

Quality Control

Our Dde-L-Phe-Ol is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive synthetic applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We adhere to cGMP principles where applicable to support our clients' regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition. For long-term storage, consider desiccation or storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Optical Rotation [α]20/D	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.