Description

Ethyl 3-(Trimethylsilyl)Propionate-2,2,3,3-D4, 99 Atom % D is a high-purity, deuterium-labeled isotopologue of ethyl 3-(trimethylsilyl)propionate, serving as a critical internal standard and tracer in advanced analytical chemistry. This compound is essential for ensuring accuracy and reliability in quantitative analyses, particularly in complex matrices where signal overlap is a challenge. It is primarily utilized by researchers and quality control laboratories in the pharmaceutical, agrochemical, and metabolomics fields for applications such as mass spectrometry, NMR spectroscopy, and pharmacokinetic studies.

Application

• Internal Standard for Mass Spectrometry (MS): Provides precise quantification in GC-MS and LC-MS analyses by compensating for matrix effects and instrument variability.
• NMR Spectroscopy Tracer: Used in mechanistic studies and metabolic pathway elucidation due to its distinct deuterium NMR signals.
• Pharmaceutical Research & Development: Critical for drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and impurity profiling.
• Metabolomics and Biomarker Discovery: Enables accurate relative and absolute quantification of metabolites in biological samples.
• Chemical Synthesis Intermediate: Acts as a deuterated building block for the synthesis of more complex labeled compounds in medicinal and organic chemistry.
• Quality Control & Reference Standard: Serves as a certified reference material (CRM) to validate analytical methods and ensure regulatory compliance in GLP/GMP environments.

Basic Information

Product Name	Ethyl 3-(Trimethylsilyl)Propionate-2,2,3,3-D4, 99 Atom % D
CAS No.	302911-89-3
Molecular Formula	C9H16D4O2Si
Molecular Weight	190.35 g/mol
Synonyms	Ethyl 3-(Trimethylsilyl)propionate-d4; Ethyl 3-(Trimethylsilyl)propanoate-2,2,3,3-d4; Ethyl 3-(TMS)propionate-d4; [2,2,3,3-2H4]Ethyl 3-(Trimethylsilyl)propionate; 3-(Trimethylsilyl)propionic-2,2,3,3-d4 acid ethyl ester; Ethyl β-(Trimethylsilyl)propionate-d4; ETSP-d4; TMS-propionate ethyl ester-d4
EINECS	Contact for details

Quality Control

Every batch of Ethyl 3-(Trimethylsilyl)Propionate-2,2,3,3-D4 is manufactured and tested under strict quality management systems to ensure the highest isotopic and chemical purity. Our products undergo rigorous quality testing, including NMR and MS analysis, to ensure compliance with specifications for research and analytical use. Certificates of Analysis (COA) detailing isotopic enrichment, chemical purity, and analytical data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under inert atmosphere. This material is moisture-sensitive; keep the container tightly sealed in a dry and well-ventilated place.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC)	≥ 98.0%
Isotopic Enrichment	≥ 99 Atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.