Description

6-Amino-8-(2-Ethoxyphenyl)-2-Ethyl-2,3,8,8A-Tetrahydroisoquinoline-5,7,7(1H)-Tricarbonitrile is a high-purity, advanced pharmaceutical intermediate with a complex polycyclic structure. This compound matters for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular architectures. It is primarily needed by R&D laboratories and production facilities in the pharmaceutical and fine chemical industries focused on developing next-generation drugs.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of complex heterocyclic drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Organic Synthesis Building Block: Utilized in research and development for constructing novel nitrogen-containing polycyclic frameworks.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore new pharmacophores and optimize drug-like properties.
• Fine Chemical Production: Used in the scaled-up manufacture of specialty chemicals requiring its specific tricyclic, multi-functionalized core.
• Contract Research & Manufacturing (CRAM): Supplied to organizations providing custom synthesis and process development services.

Basic Information

Product Name	6-Amino-8-(2-Ethoxyphenyl)-2-Ethyl-2,3,8,8A-Tetrahydroisoquinoline-5,7,7(1H)-Tricarbonitrile
CAS No.	302795-67-1
Molecular Formula	C21H20N6O
Molecular Weight	372.43 g/mol
Synonyms	6-Amino-8-(2-ethoxyphenyl)-2-ethyl-1,2,3,8-tetrahydroisoquinoline-5,7,7-tricarbonitrile; 2-Ethyl-6-amino-8-(2-ethoxyphenyl)-2,3,8,8a-tetrahydroisoquinoline-5,7,7(1H)-tricarbonitrile; 6-Amino-8-(2-ethoxyphenyl)-2-ethyl-2,3,8,8a-tetrahydro-1H-isoquinoline-5,7,7-tricarbonitrile; 302795-67-1; 6-Amino-8-(2-ethoxyphenyl)-2-ethyl-1,2,3,8-tetrahydro-5,7,7-tricarbonitrile isoquinoline
EINECS	Contact for details

Quality Control

Our 6-Amino-8-(2-Ethoxyphenyl)-2-Ethyl-2,3,8,8A-Tetrahydroisoquinoline-5,7,7(1H)-Tricarbonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed chromatographic data are provided for each lot to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.