Description

Ethyl 6-(4-Bromophenyl)-8-Methyl-4-Oxo-3,4-Dihydro-2H,6H-Pyrimido[2,1-B][1,3]Thiazine-7-Carboxylate is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 301358-79-2. This compound is a key synthetic building block valued for its complex heterocyclic structure, which is integral to the development of novel active pharmaceutical ingredients (APIs). It is primarily sought by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for process development and scale-up activities.

Application

This specialized intermediate serves critical roles in research and industrial synthesis. Its primary applications include:

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders or possessing antimicrobial activity.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging its unique fused pyrimidothiazine core.
• Chemical Synthesis: Serves as a versatile building block for constructing complex nitrogen- and sulfur-containing heterocycles in medicinal chemistry.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and pilot-scale production for new chemical entities (NCEs).
• Academic & Contract Research: Utilized in university laboratories and CROs (Contract Research Organizations) for exploratory research and method development.

Basic Information

Item	Details
Product Name	Ethyl 6-(4-Bromophenyl)-8-Methyl-4-Oxo-3,4-Dihydro-2H,6H-Pyrimido[2,1-B][1,3]Thiazine-7-Carboxylate
CAS No.	301358-79-2
Molecular Formula	C₁₇H₁₇BrN₂O₃S
Molecular Weight	409.30 g/mol
Synonyms	Ethyl 6-(4-bromophenyl)-8-methyl-4-oxo-3,4-dihydro-2H,6H-pyrimido[2,1-b][1,3]thiazine-7-carboxylate; 301358-79-2; 6-(4-Bromophenyl)-8-methyl-4-oxo-3,4-dihydro-2H,6H-pyrimido[2,1-b][1,3]thiazine-7-carboxylic acid ethyl ester; SCHEMBL2182107; BCP32633; ZINC000253899007; AKOS025147329; CTK8G0665
EINECS	Contact for details

Quality Control

Our Ethyl 6-(4-Bromophenyl)-8-Methyl-4-Oxo-3,4-Dihydro-2H,6H-Pyrimido[2,1-B][1,3]Thiazine-7-Carboxylate is produced under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, related substances, and residual solvents. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.