Description

n-(3-Cyano-5,6-Dihydro-4H-Cyclopenta[B]Thiophen-2-Yl)-4-Fluorobenzamide is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of novel active pharmaceutical ingredients (APIs). This compound is critical for research and development in medicinal chemistry, offering a versatile building block for creating targeted therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers focused on developing new drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of novel small-molecule drug candidates.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Synthesis: Serves as a critical building block in the multi-step synthesis of complex target molecules for preclinical and clinical studies.
• Oncology Drug Development: Employed in the synthesis of potential kinase inhibitors and other targeted cancer therapies due to its fused heterocyclic structure.
• CNS-Active Compound Synthesis: Utilized in creating molecules designed to cross the blood-brain barrier for neurological and psychiatric disorder research.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis and scale-up projects.
• Academic Research: Used in university and institutional labs for cutting-edge research in organic synthesis and pharmacology.

Basic Information

Product Name	n-(3-Cyano-5,6-Dihydro-4H-Cyclopenta[B]Thiophen-2-Yl)-4-Fluorobenzamide
CAS No.	300712-76-9
Molecular Formula	C15H11FN2OS
Molecular Weight	286.33 g/mol
Synonyms	4-Fluoro-N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)benzamide; 2-[(4-Fluorobenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonitrile; 4-Fluoro-N-(3-cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)benzamide; N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-4-fluorobenzamide; 300712-76-9; 4-Fluoro-N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-benzamide
EINECS	Contact for details

Quality Control

Our n-(3-Cyano-5,6-Dihydro-4H-Cyclopenta[B]Thiophen-2-Yl)-4-Fluorobenzamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable material for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.