Description

L-Tyrosine-D11 is a stable isotope-labeled analog of the essential amino acid L-Tyrosine, where eleven hydrogen atoms are replaced by deuterium. This high-purity compound is critical for advanced analytical and research applications requiring precise internal standards. It is primarily utilized by researchers and quality control laboratories in the pharmaceutical, biotechnology, and metabolomics sectors for accurate quantification and metabolic pathway tracing.

Application

• Mass Spectrometry Internal Standard: Serves as a critical quantitative reference standard in LC-MS and GC-MS analyses for accurate measurement of endogenous L-Tyrosine levels in complex biological matrices.
• Metabolic Research & Tracing: Used in deuterium-labeling studies to investigate tyrosine metabolism, protein synthesis rates, and neurotransmitter (dopamine, epinephrine) biosynthesis pathways.
• Pharmaceutical Development & PK/PD Studies: Employed in pharmacokinetic and pharmacodynamic studies to track the absorption, distribution, metabolism, and excretion of tyrosine-containing drug candidates.
• Clinical Diagnostics: Facilitates the precise measurement of tyrosine and related metabolites in patient samples for the diagnosis and monitoring of metabolic disorders like tyrosinemia.
• Nutritional & Sports Science Research: Applied in studies examining protein metabolism, muscle protein synthesis, and the physiological impact of amino acid supplementation.
• Biomarker Discovery & Validation: Acts as a stable isotope-labeled standard in proteomic and metabolomic workflows for the identification and validation of disease biomarkers.

Basic Information

Product Name	L-Tyrosine-D11
CAS No.	39748-77-1
Molecular Formula	C9D11NO3
Molecular Weight	197.25 g/mol
Synonyms	(2S)-2-Amino-3-(4-hydroxyphenyl)propanoic-2,3,3-d3 acid (ring-d5); L-Tyrosine (phenyl-d5, 3,3-d2, β-d); L-Tyrosine (ring-d5, 3,3-d2, β-d); Tyrosine-d11; (S)-Tyrosine-d11; 4-Hydroxy-DL-phenylalanine-d11; 3-(4-Hydroxyphenyl)-L-alanine-d11
EINECS	Contact for details

Quality Control

Our L-Tyrosine-D11 is manufactured under strict quality systems to ensure exceptional isotopic and chemical purity, suitable for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (D-atom %), chemical purity by HPLC, and confirmation of structure. We adhere to relevant industry standards for high-purity reference materials to guarantee reliable and reproducible performance in your research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-Atom %)	≥ 98.0%
Chemical Purity (HPLC)	≥ 98.0%
Specific Rotation	-10.0° to -12.0° (c=1 in 1N HCl)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.