Description

(R)-Ethosuximide is the single enantiomer of the established anticonvulsant ethosuximide, offering a high-purity chiral building block for advanced pharmaceutical research and development. This compound is critical for investigating stereospecific pharmacological activity and developing novel, targeted central nervous system (CNS) therapies. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in enantioselective synthesis and neuropharmacology studies.

Application

• Chiral Intermediate: A key starting material for the synthesis of novel enantiomerically pure anticonvulsant agents and CNS-active compounds.
• Pharmacological Research: Used in preclinical studies to isolate and understand the specific biological activity and metabolic profile of the (R)-enantiomer.
• Reference Standard: Serves as a high-purity analytical standard for method development and quality control in chiral HPLC or SFC analysis.
• Process Chemistry: Employed in the development and optimization of asymmetric synthesis routes within pharmaceutical manufacturing.
• Academic Research: A valuable tool for universities and research institutes studying stereochemistry, drug-receptor interactions, and epilepsy mechanisms.

Basic Information

Product Name	(R)-Ethosuximide
CAS No.	39122-20-8
Molecular Formula	C7H11NO2
Molecular Weight	141.17 g/mol
Synonyms	(R)-3-Ethyl-3-methylpyrrolidine-2,5-dione; (R)-2-Ethyl-2-methylsuccinimide; D-Ethosuximide; (R)-α-ethyl-α-methylsuccinimide; (R)-Ethosuximid; (R)-Ethymal; (R)-Zarontin; (R)-Enantiomer of Ethosuximide
EINECS	Contact for details

Quality Control

Our (R)-Ethosuximide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets exacting standards for pharmaceutical research. A Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and related substances is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.