Description

(S)-Ethosuximide CAS NO 39122-19-5 is the single enantiomer of the established anticonvulsant ethosuximide, representing a high-purity chiral building block of significant pharmaceutical interest. Its importance lies in enabling advanced research into stereoselective pharmacology and the development of next-generation, targeted central nervous system (CNS) therapies. This compound is essential for pharmaceutical R&D laboratories, fine chemical synthesis units, and academic institutions focused on chiral drug discovery and neuropharmacology.

Application

• Chiral Pharmaceutical Intermediate: A critical starting material or advanced intermediate in the research and synthesis of novel enantiomerically pure anticonvulsant drugs.
• Pharmacological Reference Standard: Used as a high-purity standard in analytical method development (HPLC, GC) and for calibrating assays in bioanalytical studies.
• Mechanism of Action Studies: Enables precise research into the stereospecific interactions and binding mechanisms of ethosuximide at T-type calcium channels in the brain.
• Metabolism and Pharmacokinetics Research: Employed to study the enantioselective metabolism, distribution, and clearance of ethosuximide in preclinical models.
• Process Chemistry Development: Serves as a key chiral template for developing and optimizing asymmetric synthesis routes in pharmaceutical manufacturing.
• Academic and Institutional Research: A vital tool for universities and research institutes conducting studies in medicinal chemistry, neurochemistry, and stereochemistry.

Basic Information

Product Name	(S)-Ethosuximide
CAS No.	39122-19-5
Molecular Formula	C7H11NO2
Molecular Weight	141.17 g/mol
Synonyms	(S)-3-Ethyl-3-methylpyrrolidine-2,5-dione; (S)-2-Ethyl-2-methylsuccinimide; (S)-α-Ethyl-α-methylsuccinimide; (S)-Ethosuximide; (-)-Ethosuximide; Levosuximide; (S)-3-Methyl-3-ethyl-2,5-pyrrolidinedione; (S)-3-Ethyl-3-methyl-2,5-dioxopyrrolidine
EINECS	Contact for details

Quality Control

Our (S)-Ethosuximide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assay, to ensure it meets the stringent requirements for pharmaceutical research and development. A detailed Certificate of Analysis (COA) providing specifications for identity, purity (HPLC), enantiomeric excess, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.