Description

L-Proline (D7) is a stable isotope-labeled analog of the essential amino acid L-Proline, where seven hydrogen atoms are replaced by deuterium. This high-purity compound is critical for advanced analytical and research applications where precise molecular tracking is required. It is primarily utilized by researchers and quality control laboratories in the pharmaceutical, biotechnology, and academic sectors for applications such as quantitative mass spectrometry and metabolic pathway studies.

Application

• Internal Standard for Quantitative Mass Spectrometry (MS): Serves as a critical reference standard in LC-MS and GC-MS analyses for the accurate quantification of endogenous proline in complex biological matrices.
• Metabolic Research & Tracing: Used in deuterium-labeling studies to investigate proline metabolism, protein synthesis rates, and collagen turnover in vivo and in vitro.
• Pharmaceutical Development: Employed in pharmacokinetic (PK) and pharmacodynamic (PD) studies for drug candidates where proline is a component, enabling precise tracking of drug absorption and distribution.
• Proteomics & Biomarker Discovery: Facilitates relative and absolute quantification (AQUA) of peptides and proteins in proteomic workflows.
• NMR Spectroscopy: Acts as a useful tool in nuclear magnetic resonance spectroscopy for structural elucidation and dynamics studies without signal interference from protons.
• Quality Control & Method Validation: Essential for developing and validating robust analytical methods in regulatory environments (GMP/GLP) for pharmaceutical quality assurance.

Basic Information

Product Name	L-Proline (D7)
CAS No.	39063-89-3
Molecular Formula	C5H2D7NO2
Molecular Weight	118.16 g/mol
Synonyms	(2S)-Pyrrolidine-2-carboxylic-2,3,3,4,4,5,5-d7 acid; L-Proline-d7; (S)-Proline-d7; Proline-2,3,3,4,4,5,5-d7; Deuterated L-Proline; L-Proline (heptadeutero); Proline (D7)
EINECS	Contact for details

Quality Control

Our L-Proline (D7) is manufactured under strict quality systems to ensure exceptional isotopic and chemical purity, suitable for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment, chemical purity, and analytical method results. We adhere to high standards relevant for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.