Description

Methyl (41R,12R,13Ar)-13A-Ethyl-12-Hydroxy-2,3,41,5,6,12,13,13A-Octahydro-1H-Indolo[3,2,1-De]Pyrido[3,2,1-Ij][1,5]Naphthyridine-12-Carboxylate is a complex, high-purity heterocyclic organic compound with a defined stereochemistry. This compound is of significant interest in advanced pharmaceutical research and development, particularly as a sophisticated synthetic intermediate or a potential pharmacophore. It is primarily sought after by research institutions and pharmaceutical companies engaged in the synthesis of novel active pharmaceutical ingredients (APIs) and complex natural product analogs. The precise stereocenters and intricate fused ring system make it a valuable building block for medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of potential therapeutic agents, especially those targeting neurological or oncological pathways.
• Medicinal Chemistry Research: Used as a scaffold or building block for structure-activity relationship (SAR) studies and library synthesis in drug discovery.
• Alkaloid Synthesis: Employed in the synthetic construction of complex indole- and isoquinoline-based alkaloid analogs for biological evaluation.
• Chemical Biology Probe Development: Utilized in the design and synthesis of molecular probes to study specific enzyme or receptor interactions.
• Process Chemistry Development: Acts as a key intermediate during the route scouting and optimization phase for new API manufacturing processes.
• Academic Research: Used in university and institutional labs for methodological studies in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	Methyl (41R,12R,13Ar)-13A-Ethyl-12-Hydroxy-2,3,41,5,6,12,13,13A-Octahydro-1H-Indolo[3,2,1-De]Pyrido[3,2,1-Ij][1,5]Naphthyridine-12-Carboxylate
CAS No.	38990-16-8
Molecular Formula	C22H26N2O3
Molecular Weight	366.46 g/mol
Synonyms	Methyl 13a-ethyl-12-hydroxy-1,2,3,4,5,6,12,13,13a,13b-decahydroindolo[3',2':4,5]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate; (12R,13aR)-Methyl 13a-ethyl-12-hydroxy-2,3,4a,5,6,12,13,13a-octahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate; Yohimbane derivative; Hexacyclic yohimbine analog; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our Methyl (41R,12R,13Ar)-13A-Ethyl-12-Hydroxy-2,3,41,5,6,12,13,13A-Octahydro-1H-Indolo[3,2,1-De]Pyrido[3,2,1-Ij][1,5]Naphthyridine-12-Carboxylate is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets exacting research-grade specifications. A detailed Certificate of Analysis (COA) providing batch-specific data is supplied with every order to guarantee traceability and consistency for your critical R&D applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. This compound may be light-sensitive and/or hygroscopic; prolonged exposure to light, heat, or moisture should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 97.0%
Chiral Purity	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.