Description

(5S)-5,8,9,14,14Bβ,15-Hexahydro-5-Hydroxy-6H-Pyrido[4'',3'':4',5']Azepino[1',2':1,2]Pyrido[3,4-B]Indole-1-Carboxylic Acid Methyl Ester is a complex, high-purity heterocyclic organic compound of significant interest in advanced pharmaceutical research and development. This molecule serves as a critical synthetic intermediate or a key pharmacophore for the creation of novel therapeutic agents targeting central nervous system and other disorders. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of complex active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex drug candidates, particularly those with polycyclic alkaloid-like structures.
• Neurological Research: Used in the development of novel compounds targeting receptors and enzymes within the central nervous system.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies to optimize potency, selectivity, and pharmacokinetic properties.
• Reference Standard: Supplied as a high-purity analytical standard for method development, quality control, and regulatory submissions in drug development pipelines.
• Process Chemistry Development: Utilized for scaling up synthetic routes from milligram to kilogram scale under current Good Manufacturing Practice (cGMP) conditions.
• Academic Research: Employed in university and institutional labs for cutting-edge research in organic synthesis and pharmacology.

Basic Information

Item	Details
Product Name	(5S)-5,8,9,14,14Bβ,15-Hexahydro-5-Hydroxy-6H-Pyrido[4'',3'':4',5']Azepino[1',2':1,2]Pyrido[3,4-B]Indole-1-Carboxylic Acid Methyl Ester
CAS No.	38940-73-7
Molecular Formula	C22H21N3O3
Molecular Weight	375.42 g/mol
Synonyms	Methyl (5S)-5,8,9,14,14b,15-hexahydro-5-hydroxy-6H-pyrido[4",3":4',5']azepino[1',2':1,2]pyrido[3,4-b]indole-1-carboxylate; (5S)-5,8,9,14,14b,15-Hexahydro-5-hydroxy-6H-pyrido[4",3":4',5']azepino[1',2':1,2]pyrido[3,4-b]indole-1-carboxylic acid methyl ester; Yohimbine-related intermediate; Pyridoazepinoindole derivative.
EINECS	Contact for details

Quality Control

Our (5S)-5,8,9,14,14Bβ,15-Hexahydro-5-Hydroxy-6H-Pyrido[4'',3'':4',5']Azepino[1',2':1,2]Pyrido[3,4-B]Indole-1-Carboxylic Acid Methyl Ester is produced and tested under a rigorous quality management system. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, related substances, and residual solvents. We can supply material compliant with research-grade through to cGMP standards to meet your specific project phase requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). For long-term storage, consider storing under an inert atmosphere to maintain stability. Keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.