Description

n-Succinimidyl Methacrylate is a high-purity, reactive ester monomer widely used as a versatile heterobifunctional crosslinking agent. Its core value lies in enabling the controlled conjugation of methacrylate groups to primary amines under mild conditions, facilitating the synthesis of functional polymers and biomolecule-polymer hybrids. This compound is essential for researchers and manufacturers in the fields of advanced polymer chemistry, bioconjugation, and the development of stimuli-responsive materials and drug delivery systems.

Application

• Bioconjugation and Protein Labeling: Functionalizing antibodies, enzymes, and other proteins with polymerizable methacrylate groups for hydrogel immobilization or surface grafting.
• Synthesis of Functional Monomers: Serving as a key intermediate for creating amine-reactive monomers used in controlled radical polymerization (e.g., ATRP, RAFT).
• Hydrogel and Biomaterial Fabrication: Crosslinking agent for producing amine-containing hydrogels with tailored mechanical properties and degradation profiles for tissue engineering.
• Surface Modification: Crafting reactive polymer brushes or coatings on amine-functionalized surfaces (e.g., silicon, gold, polymers) for sensor or diagnostic device applications.
• Drug Delivery System Development: Conjugating therapeutic agents or targeting ligands to polymer backbones to create smart, stimuli-responsive nanocarriers.
• Chromatography Media: Derivatization of stationary phases for affinity chromatography or specialized separation techniques.

Basic Information

Product Name	n-Succinimidyl Methacrylate
CAS No.	38862-25-8
Molecular Formula	C8H9NO4
Molecular Weight	183.16 g/mol
Synonyms	N-Methacryloxysuccinimide; Succinimidyl Methacrylate; N-(Methacryloyloxy)succinimide; Methacrylic Acid N-Hydroxysuccinimide Ester; NHS Methacrylate; 2,5-Dioxopyrrolidin-1-yl 2-methylprop-2-enoate; N-SMA
EINECS	Contact for details

Quality Control

Our n-Succinimidyl Methacrylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and FT-IR, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) with detailed batch-specific results are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or CoA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.