Description

n-Chloroacetylsuccinimide is a versatile and highly reactive succinimide derivative used as a key acylating and chloroacetylating agent in organic synthesis. Its primary value lies in its ability to efficiently introduce the chloroacetyl moiety, a crucial functional group for constructing more complex molecules, particularly in pharmaceutical and agrochemical research. This compound is essential for chemists and process engineers in the fine chemical, pharmaceutical intermediate, and advanced material sectors who require a reliable, high-purity building block for custom synthesis and process development.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent for the chloroacetylation of amines and alcohols in the production of active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Manufacturing: Used in the synthesis of herbicides, fungicides, and pesticides where the chloroacetyl group is a critical structural component.
• Peptide Chemistry: Serves as a protecting group or activating agent in the synthesis of modified peptides and peptidomimetics.
• Polymer & Material Science: Employed as a monomer or cross-linking agent to create functional polymers with specific chemical properties.
• Custom & Contract Synthesis: A valuable tool for research and development (R&D) laboratories and CDMOs (Contract Development and Manufacturing Organizations) for besolecule creation.
• Bioconjugation: Facilitates the labeling and modification of biomolecules for diagnostic and research applications.

Basic Information

Product Name	n-Chloroacetylsuccinimide
CAS No.	38766-10-8
Molecular Formula	C6H6ClNO3
Molecular Weight	175.57 g/mol
Synonyms	N-Chloroacetylsuccinimide; Chloroacetyl Succinimide; 1-(Chloroacetyl)-2,5-pyrrolidinedione; 1-(Chloroacetyl)pyrrolidine-2,5-dione; Succinimide, N-chloroacetyl-; CAS 38766-10-8; Chloroacetyl succinimide
EINECS	Contact for details

Quality Control

Our n-Chloroacetylsuccinimide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) with detailed specifications are provided with every shipment to guarantee traceability, consistency, and reliability for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	118 - 122 °C
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.