Description

(3R)-3,4-Dihydro-6,8-Dihydroxy-3-[[(2R,6S)-Tetrahydro-5-Hydroxy-6-Methyl-2H-Pyran-2-Yl]Methyl]-1H-2-Benzopyran-1-One is a complex chiral isocoumarin derivative with significant biological relevance. This high-purity compound is valued for its role as a key intermediate in advanced pharmaceutical synthesis and research. It is primarily sought by R&D and production teams in the pharmaceutical, biotechnology, and fine chemical sectors for developing novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of complex active pharmaceutical ingredients (APIs) and potential drug candidates.
• Biochemical Research: Used as a reference standard or probe in enzymatic studies and metabolic pathway research due to its specific stereochemistry.
• Natural Product Synthesis: Serves as a core structural unit in the total synthesis of natural products containing the isocoumarin or chromane scaffold.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to explore and optimize biological activity for new therapeutic targets.
• Process Development: Used in scaling up synthetic routes and developing robust, GMP-compliant manufacturing processes for advanced intermediates.

Basic Information

Product Name	(3R)-3,4-Dihydro-6,8-Dihydroxy-3-[[(2R,6S)-Tetrahydro-5-Hydroxy-6-Methyl-2H-Pyran-2-Yl]Methyl]-1H-2-Benzopyran-1-One
CAS No.	38747-39-6
Molecular Formula	C₁₆H₂₀O₆
Molecular Weight	308.33 g/mol
Synonyms	3,4-Dihydro-6,8-dihydroxy-3-[(tetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl)methyl]-1H-2-benzopyran-1-one; (3R,2'R,6'S)-3,4-Dihydro-6,8-dihydroxy-3-[(tetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl)methyl]-1H-2-benzopyran-1-one; Isocoumarin derivative 38747-39-6; Chiral isocoumarin intermediate; (R)-3,4-Dihydro-6,8-dihydroxy-3-((2R,6S)-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)methyl)isochroman-1-one
EINECS	Contact for details

Quality Control

Our (3R)-3,4-Dihydro-6,8-Dihydroxy-3-[[(2R,6S)-Tetrahydro-5-Hydroxy-6-Methyl-2H-Pyran-2-Yl]Methyl]-1H-2-Benzopyran-1-One is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP intermediate applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.