Description

Seneciphylline n-Oxide is a pyrrolizidine alkaloid derivative, specifically the N-oxide form of seneciphylline, known for its role as a reference standard and a key compound in phytochemical research. Its significance lies in its utility for the accurate identification, quantification, and toxicological study of pyrrolizidine alkaloids in plant materials and herbal products. This high-purity compound is essential for researchers and quality control laboratories in the pharmaceutical, nutraceutical, and botanical extract industries who require reliable analytical standards to ensure product safety and regulatory compliance.

Application

• Analytical Reference Standard: Primary use as a certified reference material (CRM) for HPLC, LC-MS, and GC-MS analysis in laboratory settings.
• Phytochemical Research: Used in the isolation, characterization, and metabolic pathway studies of pyrrolizidine alkaloids.
• Toxicology and Safety Assessment: Critical for calibrating equipment and developing methods to detect and quantify potentially hepatotoxic pyrrolizidine alkaloid contaminants in food, feed, and herbal supplements.
• Method Development and Validation: Serves as a benchmark compound for establishing and validating new analytical protocols in compliance with pharmacopeial guidelines (e.g., USP, EP).
• Quality Control in Manufacturing: Employed by manufacturers of botanical extracts to test for the presence and levels of specific alkaloids, ensuring batch-to-batch consistency and purity.
• Academic and Institutional Research: Used in university and government labs for studies on plant biochemistry, natural product chemistry, and the biosynthetic origins of alkaloids.

Basic Information

Product Name	Seneciphylline n-Oxide
CAS No.	38710-26-8
Molecular Formula	C18H23NO6
Molecular Weight	349.38 g/mol
Synonyms	Seneciphylline N-Oxide; 12,13-Didehydro-9,10-dehydrosenecionan-11,16-dione, 19-methyl-, 1-oxide; (13Z)-Senecionan-11,16-dione, 19-methyl-, 1-oxide; Seneciphylline 1-oxide; Seneciphylline oxide; Jacobine N-oxide (related isomer); PA N-oxide standard
EINECS	Contact for details

Quality Control

Our Seneciphylline n-Oxide is produced and handled under strict quality management protocols. Each batch undergoes rigorous identity confirmation and purity analysis using advanced techniques including HPLC, NMR, and mass spectrometry to ensure it meets the high standards required for reference materials. A comprehensive Certificate of Analysis (COA) detailing purity, analytical methods, and results is provided with every shipment to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive (store away from light). For long-term storage, consider desiccated conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.