Description

trans-10,11-Dihydroxycarbamazepine is a key pharmaceutical intermediate and metabolite of the anticonvulsant drug carbamazepine. This compound is of significant importance for analytical research, method development, and the synthesis of related active pharmaceutical ingredients. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories engaged in drug metabolism studies, pharmacokinetics, and quality control testing.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quantitative and qualitative analysis of carbamazepine and its metabolites in biological matrices and finished drug products.
• Metabolite Studies: Critical for in-vitro and in-vivo drug metabolism and pharmacokinetics (DMPK) research to understand the metabolic pathway of carbamazepine.
• Impurity Profiling: Used as an impurity marker in the development and validation of HPLC/LC-MS methods to ensure the purity and safety of carbamazepine-based pharmaceuticals.
• Organic Synthesis: Acts as a versatile building block for the synthesis of novel carbamazepine derivatives and analogs in medicinal chemistry research.
• Clinical Research: Employed in therapeutic drug monitoring (TDM) studies to correlate metabolite levels with drug efficacy and toxicity.

Basic Information

Product Name	trans-10,11-Dihydroxycarbamazepine
CAS No.	106758-94-5
Molecular Formula	C15H12N2O3
Molecular Weight	268.27 g/mol
Synonyms	10,11-Dihydro-10,11-trans-dihydroxycarbamazepine; CBZ-diol; trans-Carbamazepine-10,11-dihydrodiol; (10R,11R)-10,11-Dihydro-10,11-dihydroxy-5H-dibenzo[b,f]azepine-5-carboxamide; (10S,11S)-10,11-Dihydro-10,11-dihydroxy-5H-dibenzo[b,f]azepine-5-carboxamide; trans-Dihydroxycarbamazepine; Carbamazepine-10,11-diol; NSC 339539
EINECS	Contact for details

Quality Control

Our trans-10,11-Dihydroxycarbamazepine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing all test results against established specifications. Our quality commitment ensures material suitable for demanding pharmaceutical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.