Description

(2-Bromophenylethynyl)Trimethylsilane is a versatile organosilicon building block featuring both a bromoaryl and a protected terminal alkyne functional group. This compound is essential for advanced organic synthesis, enabling efficient cross-coupling and functional group transformations. It is primarily sought after by researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates via Sonogashira and other palladium-catalyzed cross-coupling reactions.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides that require arylacetylene structural motifs.
• Material Science & OLED Development: Serves as a monomer or building block for creating conjugated polymers, organic semiconductors, and light-emitting materials for electronic devices.
• Ligand & Catalyst Preparation: Employed in the synthesis of specialized phosphine or N-heterocyclic carbene (NHC) ligands used in homogeneous catalysis.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D in exploring new synthetic methodologies and creating molecular libraries.
• Protecting Group Strategy: The trimethylsilyl (TMS) group acts as a protective moiety for the terminal alkyne, which can be selectively deprotected under mild conditions for further functionalization.

Basic Information

Product Name	(2-Bromophenylethynyl)Trimethylsilane
CAS No.	38274-16-7
Molecular Formula	C11H13BrSi
Molecular Weight	253.21 g/mol
Synonyms	1-Bromo-2-[(trimethylsilyl)ethynyl]benzene; 2-Bromophenylacetylene trimethylsilyl ether; o-Bromo((trimethylsilyl)ethynyl)benzene; Trimethyl(2-bromophenylethynyl)silane; (2-Bromophenyl)ethynyltrimethylsilane; TMS-Protected 2-Bromophenylacetylene; 2-Bromo-ω-(trimethylsilyl)ethynylbenzene
EINECS	Contact for details

Quality Control

Our (2-Bromophenylethynyl)Trimethylsilane is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including GC, HPLC, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.