Description

(1R,4S,6R)-7-Oxabicyclo[2.2.1]heptane-6-carboxylic acid is a high-purity chiral building block and advanced pharmaceutical intermediate. This compound is valued for its rigid, bicyclic oxanorbornane scaffold, which is instrumental in imparting specific three-dimensional conformation and stability to target molecules. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly in areas requiring sophisticated stereochemical control.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the synthesis of complex drug candidates, especially for central nervous system (CNS) and antiviral therapeutics.
• Asymmetric Synthesis: Utilized as a precursor or ligand in catalytic asymmetric reactions to construct molecules with high enantiomeric purity.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore new chemical entities and optimize pharmacological profiles.
• Peptidomimetics & Prodrug Design: Its carboxylic acid functionality and constrained structure make it suitable for designing peptide mimics and prodrug linkers.
• Agrochemical Synthesis: Potential use as an intermediate in the development of advanced, stereospecific agrochemicals and plant protection agents.
• Material Science: Can be investigated as a monomer or cross-linking agent for creating polymers with unique thermal and mechanical properties.

Basic Information

Product Name	(1R,4S,6R)-7-Oxabicyclo[2.2.1]heptane-6-carboxylic Acid
CAS No.	38263-56-8
Molecular Formula	C7H10O3
Molecular Weight	142.15 g/mol
Synonyms	(1R,4S,6R)-7-Oxabicyclo[2.2.1]heptane-6-carboxylic Acid; (-)-7-Oxabicyclo[2.2.1]hept-5-ene-2-exo-carboxylic Acid (specific isomer); (1R,4S,6R)-1,4-Epoxy-1,3,3-trimethyl-2-oxabicyclo[2.2.1]heptane-6-carboxylic Acid; exo-(-)-3-Oxabicyclo[3.2.0]hept-6-ene-6-carboxylic Acid (related structure); Oxanorbornane-6-carboxylic Acid derivative; Chiral Oxabicycloheptane Carboxylic Acid.
EINECS	Contact for details

Quality Control

Our (1R,4S,6R)-7-Oxabicyclo[2.2.1]heptane-6-carboxylic acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, enantiomeric excess, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product may be hygroscopic (moisture-sensitive); keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.