Description

5-Bromo-2H-chromen-2-one is a halogenated coumarin derivative, a versatile and important organic building block in advanced chemical synthesis. Its core value lies in its bromine substituent, which provides a reactive site for further functionalization via cross-coupling reactions, making it a critical intermediate for creating complex molecular architectures. This compound is primarily needed by research institutions and industrial R&D departments in the pharmaceutical, agrochemical, and material science sectors for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly those targeting various enzyme families where the coumarin scaffold is pharmacologically active.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and pesticides, leveraging its heterocyclic structure for bioactivity.
• Organic Light-Emitting Diodes (OLEDs): Acts as a building block for electron-transport materials or emissive layer dopants due to the coumarin core's photophysical properties.
• Fluorescent Probe Synthesis: Employed in creating sensitive chemical sensors and bio-imaging agents, where bromination allows for attachment of targeting groups.
• Material Science: Utilized in the preparation of advanced polymers and coatings with specific optical or electronic characteristics.
• Academic & Contract Research: A valuable reagent for methodological studies in organic chemistry, including Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions.

Basic Information

Product Name	5-Bromo-2H-chromen-2-one
CAS No.	38169-99-2
Molecular Formula	C9H5BrO2
Molecular Weight	225.04 g/mol
Synonyms	5-Bromocoumarin; 5-Bromo-2H-1-benzopyran-2-one; 5-Bromo-1,2-benzopyrone; 5-Bromochromen-2-one; 5-Bromo-2-oxo-2H-chromene; 5-Bromo-2H-1-benzopyran-2-one; 5-Brom-2H-chromen-2-on (German); 5-ブロモ-2H-クロメン-2-オン (Japanese)
EINECS	Contact for details

Quality Control

Our 5-Bromo-2H-chromen-2-one is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	158 - 162 °C
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.