Description

4-Methoxyphenylphosphonic Dichloride is a high-purity organophosphorus reagent, specifically a phosphonic dichloride derivative. This compound is a critical synthetic intermediate valued for its high reactivity, enabling the efficient introduction of the 4-methoxyphenylphosphonate moiety into target molecules. It is primarily required by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications such as the synthesis of biologically active compounds, ligands, and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, including kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and plant growth regulators containing phosphonate groups.
• Ligand and Catalyst Preparation: Serves as a precursor for phosphonate-based ligands used in homogeneous catalysis and metal-organic frameworks (MOFs).
• Polymer Modification: Employed to incorporate phosphonate functionalities into polymers to alter properties like flame retardancy, adhesion, or metal chelation.
• Peptide Mimetics and Prodrugs: Utilized in medicinal chemistry to create phosphonate-based peptide analogs and prodrugs with enhanced stability or bioavailability.
• Chemical Research & Development: A versatile reagent for exploring new reaction pathways and creating specialized organophosphorus compounds in academic and industrial labs.

Basic Information

Product Name	4-Methoxyphenylphosphonic Dichloride
CAS No.	37632-18-1
Molecular Formula	C7H7Cl2O3P
Molecular Weight	241.01 g/mol
Synonyms	(4-Methoxyphenyl)phosphonic Dichloride; p-Methoxyphenylphosphonic Dichloride; Phosphonic Dichloride, (4-Methoxyphenyl)-; 4-Methoxybenzenephosphonic Dichloride; 4-Methoxybenzenedichlorophosphine Oxide; 4-Methoxyphenylphosphonyl Dichloride
EINECS	Contact for details

Quality Control

Our 4-Methoxyphenylphosphonic Dichloride is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.