Description

2,4,5-Trimethoxy-n-(1,2,3,4-Tetrahydro-2-Methylisoquinolin-5-Yl)Benzamide is a specialized organic compound belonging to the class of substituted isoquinoline benzamides. This molecule matters as a key synthetic intermediate or potential pharmacophore in advanced research and development, particularly for its structural complexity and functional group diversity. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of novel bioactive compounds, including potential central nervous system (CNS) agents and alkaloid derivatives.

Application

• Pharmaceutical Research & Development: Serves as a critical building block or reference standard in the synthesis of novel drug candidates, particularly those targeting neurological pathways.
• Medicinal Chemistry: Used as a core scaffold for structure-activity relationship (SAR) studies to explore and optimize biological activity.
• Biochemical Research: May be utilized as a tool compound or ligand in biochemical assays to study enzyme inhibition or receptor binding.
• Fine Chemical Synthesis: Acts as a high-value intermediate for the multi-step synthesis of complex natural product analogs or specialty chemicals.
• Academic Research: Employed in university and institutional labs for studies in organic synthesis methodology and heterocyclic chemistry.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or non-GMP conditions.

Basic Information

Product Name	2,4,5-Trimethoxy-n-(1,2,3,4-Tetrahydro-2-Methylisoquinolin-5-Yl)Benzamide
CAS No.	37481-40-6
Molecular Formula	C22H26N2O4
Molecular Weight	382.46 g/mol
Synonyms	5-[(2,4,5-Trimethoxybenzoyl)amino]-2-methyl-1,2,3,4-tetrahydroisoquinoline; 2-Methyl-5-[(2,4,5-trimethoxybenzoyl)amino]-1,2,3,4-tetrahydroisoquinoline; N-(2-Methyl-1,2,3,4-tetrahydroisoquinolin-5-yl)-2,4,5-trimethoxybenzamide; Benzamide, N-(1,2,3,4-tetrahydro-2-methyl-5-isoquinolinyl)-2,4,5-trimethoxy-; 37481-40-6; 2,4,5-Trimethoxy-N-(2-methyl-1,2,3,4-tetrahydroisoquinolin-5-yl)benzamide
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We offer material suitable for research and development purposes, with typical purity levels meeting or exceeding 95% (by HPLC). Identity is confirmed via spectroscopic methods (NMR, IR, MS). Certificates of Analysis (COA) detailing batch-specific results for identity, purity, and related substances are available upon request. We adhere to a quality management system and can provide support for regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.