Description

1-(Chloromethyl)-6,7-Dimethoxy-1,2,3,4-Tetrahydroisoquinoline Hydrochloride is a high-purity, synthetically versatile organic salt that serves as a critical building block in advanced chemical synthesis. Its value lies in its functionalized tetrahydroisoquinoline core, which is a privileged scaffold in medicinal chemistry, enabling the development of novel pharmacologically active compounds. This intermediate is essential for research and development laboratories and production facilities in the pharmaceutical and fine chemical industries, particularly those focused on central nervous system (CNS) agents and alkaloid-derived therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potent bioactive molecules, including potential candidates for neurological and cardiovascular diseases.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing compound libraries in drug discovery programs targeting receptor modulation.
• Alkaloid Synthesis: Serves as a fundamental building block for the semi-synthesis or total synthesis of complex tetrahydroisoquinoline alkaloids and their analogs.
• Chemical Biology Probes: Employed in the development of labeled compounds or probes for studying biological pathways and enzyme functions.
• Process Chemistry Development: Utilized in route scouting and optimization for the scalable production of active pharmaceutical ingredients (APIs).

Basic Information

Item	Details
Product Name	1-(Chloromethyl)-6,7-Dimethoxy-1,2,3,4-Tetrahydroisoquinoline Hydrochloride
CAS No.	37462-44-5
Molecular Formula	C₁₂H₁₇Cl₂NO₂
Molecular Weight	278.17 g/mol
Synonyms	6,7-Dimethoxy-1-(chloromethyl)-1,2,3,4-tetrahydroisoquinoline Hydrochloride; 1-(Chloromethyl)-6,7-dimethoxy-3,4-dihydroisoquinoline Hydrochloride; 1-Chloromethyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline HCl; NSC 163049; Tetrahydroisoquinoline derivative, 1-(chloromethyl)-6,7-dimethoxy-, hydrochloride
EINECS	Contact for details

Quality Control

Our 1-(Chloromethyl)-6,7-Dimethoxy-1,2,3,4-Tetrahydroisoquinoline Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports applications requiring high standards, such as pharmaceutical R&D and cGMP-compliant production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider using a desiccator or inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.