Description

L-Terbutaline is a selective β-2 adrenergic receptor agonist, a key pharmaceutical intermediate and active pharmaceutical ingredient (API) of significant commercial importance. Its primary value lies in its role as the active enantiomer in the synthesis of bronchodilator medications used to treat respiratory conditions such as asthma and chronic obstructive pulmonary disease (COPD). This high-purity compound is essential for manufacturers in the pharmaceutical and fine chemical industries who require reliable, specification-grade raw materials for producing effective and safe therapeutics.

Application

• Pharmaceutical API Synthesis: Primary use as the active enantiomer in the manufacture of terbutaline sulfate, a bronchodilator medication.
• Respiratory Drug Formulation: Critical intermediate for producing inhalers, tablets, and injectable solutions for asthma and COPD management.
• Research & Development: Used in biochemical and pharmacological research to study β-2 adrenergic receptor mechanisms and signaling pathways.
• Veterinary Medicine: Component in formulations for treating bronchospasm in animals.
• Reference Standard: Serves as a high-purity chromatographic standard for quality control and analytical method development in pharmaceutical labs.
• Asymmetric Synthesis: Valuable chiral building block for the synthesis of other complex, enantiomerically pure pharmaceutical compounds.

Basic Information

Product Name	L-Terbutaline
CAS No.	37394-31-3
Molecular Formula	C12H19NO3
Molecular Weight	225.29 g/mol
Synonyms	(−)-Terbutaline; (R)-Terbutaline; (R)-1-(3,5-Dihydroxyphenyl)-2-(tert-butylamino)ethanol; Levoterbutaline; Terbutaline (L-Form); Terbutaline Enantiomer; KWD 2019; Bricanyl (active enantiomer); Arubendol
EINECS	253-492-9

Quality Control

Our L-Terbutaline is manufactured under strict quality management systems to ensure it meets the rigorous standards required for pharmaceutical applications. Each batch is tested against comprehensive specifications, including chiral purity, chemical assay, and impurity profiles, utilizing advanced analytical techniques like HPLC and chiral chromatography. A Certificate of Analysis (COA) detailing all test results is provided with every shipment. We support compliance with cGMP, ICH Q7 guidelines, and relevant pharmacopoeial standards (USP/EP) for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time conforms to reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (Enantiomeric Excess)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.