Description

6-[(Trimethylsilyl)Oxy]-3-Pyridinecarboxylic Acid Trimethylsilyl Ester is a key organosilicon-protected intermediate in advanced organic synthesis. This compound is specifically designed to facilitate complex chemical transformations by offering dual silyl protection for both the carboxylic acid and hydroxyl groups on the pyridine ring. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex heterocyclic compounds.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of complex drug candidates, particularly those containing functionalized pyridine cores.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides where the protected pyridine moiety is required for selective reactions.
• Material Science Research: Serves as a precursor for creating functionalized ligands or monomers in specialty polymers and advanced materials.
• Organic Synthesis Reagent: Enables multi-step synthesis by protecting sensitive functional groups under harsh reaction conditions, allowing for sequential modifications.
• Academic & Industrial R&D: Employed in research laboratories for methodological development and exploring new chemical spaces in heterocyclic chemistry.

Basic Information

Product Name	6-[(Trimethylsilyl)Oxy]-3-Pyridinecarboxylic Acid Trimethylsilyl Ester
CAS No.	36972-82-4
Molecular Formula	C14H25NO3Si2
Molecular Weight	311.53 g/mol
Synonyms	3-Pyridinecarboxylic acid, 6-[(trimethylsilyl)oxy]-, trimethylsilyl ester; 6-Hydroxynicotinic Acid Bis(trimethylsilyl) Ether; 6-(Trimethylsiloxy)nicotinic Acid Trimethylsilyl Ester; Bis(trimethylsilyl) 6-hydroxynicotinate; TMS-protected 6-hydroxynicotinic acid; 6-TMS-Oxy-nicotinic Acid TMS Ester; 6-OTMS Nicotinic Acid OTMS Ester
EINECS	Contact for details

Quality Control

Our production of 6-[(Trimethylsilyl)Oxy]-3-Pyridinecarboxylic Acid Trimethylsilyl Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials are characterized by advanced analytical techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.