Description

2-(4-Methylbenzenesulfonyl)-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid is a high-purity synthetic organic compound belonging to the tetrahydroisoquinoline class, functionalized with a tosyl protecting group and a carboxylic acid moiety. This specific molecular architecture makes it a critical building block and key intermediate in advanced organic synthesis, particularly for pharmaceutical research and development. It is primarily needed by research institutions, pharmaceutical companies, and fine chemical manufacturers engaged in the synthesis of complex molecules for drug discovery programs.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel drug candidates, particularly those targeting neurological and cardiovascular pathways.
• Organic Synthesis Building Block: Used for constructing complex heterocyclic frameworks and introducing specific functional groups in multi-step synthetic routes.
• Protecting Group Chemistry: The tosyl (4-methylbenzenesulfonyl) group can act as a protective group for amines in complex synthetic sequences.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and the development of compound libraries for high-throughput screening.
• Chemical Reference Standard: Used as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Academic Research: Utilized in universities and research institutes for studying reaction mechanisms and developing new synthetic methodologies.

Basic Information

Product Name	2-(4-Methylbenzenesulfonyl)-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid
CAS No.	36842-73-6
Molecular Formula	C18H17NO4S
Molecular Weight	343.40 g/mol
Synonyms	2-(p-Toluenesulfonyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid; 2-Tosyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; 3-Carboxy-2-(p-tolylsulfonyl)-1,2,3,4-tetrahydroisoquinoline; 1,2,3,4-Tetrahydro-2-[(4-methylphenyl)sulfonyl]-3-isoquinolinecarboxylic acid; 2-(4-Methylphenylsulfonyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic Acid; Tic-Tosyl derivative; THIQ-3-COOH-Ts
EINECS	Contact for details

Quality Control

Our 2-(4-Methylbenzenesulfonyl)-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring the material meets the stringent requirements for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed when not in use to prevent absorption of atmospheric moisture. Store away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.