Description

4-Oxo-2,2,6,6-Tetramethylpiperidine-D16-1-Oxyl is a deuterated, stable nitroxide radical derivative of the TEMPO (2,2,6,6-tetramethylpiperidin-1-oxyl) family. This compound is a critical tool in advanced research, serving as a spin label and probe in Electron Paramagnetic Resonance (EPR) spectroscopy and as a mediator in controlled radical polymerization. It is essential for scientists and engineers in the fields of polymer chemistry, materials science, and biophysical research who require isotopically labeled probes for mechanistic studies, structural analysis, and the development of novel polymeric materials. The product is supplied with a high degree of isotopic purity and structural integrity.

Application

• EPR/ESR Spectroscopy: Acts as a stable, deuterated spin label for probing molecular dynamics, membrane fluidity, and protein structure in biological and synthetic systems.
• Polymer Science & Controlled Radical Polymerization: Serves as a mediator or catalyst in techniques like Nitroxide-Mediated Polymerization (NMP) for synthesizing polymers with controlled architecture and molecular weight.
• Materials Research: Used as a molecular probe to study free radical processes, oxidation mechanisms, and the properties of advanced materials like gels and composites.
• Biophysical Studies: Employed to label biomolecules (e.g., proteins, lipids) for investigating conformational changes, interactions, and distances via site-directed spin labeling (SDSL).
• Analytical Chemistry: Functions as a standard or reference compound in analytical methods development and validation for radical detection.
• Antioxidant Research: Studied as a model compound for understanding the scavenging activity and kinetics of nitroxide-based antioxidants.

Basic Information

Product Name	4-Oxo-2,2,6,6-Tetramethylpiperidine-D16-1-Oxyl
CAS No.	36763-53-8
Molecular Formula	C9D16NO2
Molecular Weight	188.33 g/mol
Synonyms	4-Oxo-TEMPO-d16; 4-Oxo-2,2,6,6-tetramethyl-1-piperidinyloxy-d16; 4-Oxo-2,2,6,6-tetramethylpiperidine-1-oxyl-d16; Deuterated 4-Oxo-TEMPO; 4-Oxo-TEMPO Deuterated; 4-OxoTEMPO-d16; 2,2,6,6-Tetramethyl-4-oxopiperidine-1-oxyl-d16; Perdeuterated 4-Oxo-TEMPO Radical
EINECS	Contact for details

Quality Control

Our 4-Oxo-2,2,6,6-Tetramethylpiperidine-D16-1-Oxyl is manufactured under strict quality protocols to ensure high isotopic and chemical purity, which is critical for sensitive spectroscopic applications. Each batch is characterized by advanced analytical techniques including NMR (¹H, ¹³C, ²H), EPR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (D-atom %), radical purity, and chemical assay is provided with every shipment to guarantee traceability and compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). For long-term stability, consider storage under an inert atmosphere (e.g., argon or nitrogen) to minimize potential degradation of the nitroxide radical.

Specification

Item	Specification
Appearance	Orange to red crystalline powder
Identification (EPR)	Conforms to structure
Identification (MS)	Conforms to structure
Deuterium Content (D-atom %)	≥ 98%
Purity (HPLC)	≥ 98%
EPR Signal Intensity	Conforms to standard
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.