Description

Cotarnine Hydrochloride is a pharmaceutical-grade alkaloid salt, a key intermediate and reference standard in medicinal chemistry research and development. Its primary value lies in its role as a derivative of narcotine, making it crucial for the synthesis and analytical study of isoquinoline-based compounds. This high-purity material is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors, particularly those focused on developing or producing central nervous system (CNS) agents and antitussive medications.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of more complex isoquinoline alkaloids and their derivatives.
• Reference Standard: Used as a certified reference material (CRM) for quality control, method validation, and analytical testing in pharmaceutical laboratories.
• Medicinal Chemistry Research: A vital compound for structure-activity relationship (SAR) studies and the development of new therapeutic agents targeting specific biological pathways.
• Active Pharmaceutical Ingredient (API) Manufacturing: Employed in the production of specific pharmaceutical formulations where cotarnine or its salts are the active component.
• Biochemical Research: Utilized in pharmacological studies to investigate the effects and mechanisms of isoquinoline alkaloids.
• Fine Chemical Synthesis: Acts as a specialized reagent for constructing complex molecular architectures in advanced organic synthesis.

Basic Information

Product Name	Cotarnine Hydrochloride
CAS No.	36647-02-6
Molecular Formula	C12H15NO4·HCl
Molecular Weight	273.71 g/mol
Synonyms	Cotarnine Chloride; Cotarnine HCl; 6,7-Dimethoxy-1-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-2(1H)-isoquinolinone Hydrochloride; Narcotine Derivative Hydrochloride; 1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methyl-1-[(3,4-methylenedioxy)phenyl]isoquinolin-8-ol Hydrochloride; Cotarninium Chloride
EINECS	Contact for details

Quality Control

Our Cotarnine Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including identification by IR and NMR, purity assay by HPLC, and control of specific impurities. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.