Description

(1S,2R)-Tramadol Hydrochloride is the specific, active enantiomer of the centrally acting analgesic tramadol. This high-purity chiral compound is critical for pharmaceutical research and development, offering a targeted approach to studying opioid receptor activity and pain management pathways. It is primarily required by pharmaceutical manufacturers, analytical laboratories, and research institutions engaged in the development of enantiomerically pure active pharmaceutical ingredients (APIs), novel analgesic formulations, and reference standards.

Application

• Pharmaceutical API Intermediate: Key chiral building block for the synthesis of enantiomerically pure tramadol-based analgesics.
• Analytical Reference Standard: Used in HPLC, GC, and chiral separation methods for quality control and assay development.
• Pharmacological Research: Essential for studying the specific binding affinity, metabolic pathways, and efficacy of the (1S,2R)-enantiomer.
• Method Development and Validation: Serves as a pure standard for developing and validating analytical methods in compliance with ICH guidelines.
• Impurity Profiling: Used to identify and quantify isomeric impurities in racemic tramadol or final drug products.
• Preclinical Studies: Employed in animal models to investigate the distinct pharmacokinetic and pharmacodynamic profile of this enantiomer.

Basic Information

Product Name	(1S,2R)-Tramadol Hydrochloride
CAS No.	36474-71-2
Molecular Formula	C16H25NO2 • HCl
Molecular Weight	299.84 g/mol (Free base: 263.38)
Synonyms	(+)-Tramadol Hydrochloride; (1S,2R)-(+)-Tramadol HCl; Tramadol (1S,2R)-enantiomer hydrochloride; (1S,2R)-2-[(Dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol hydrochloride; cis-(+)-Tramadol Hydrochloride; UNII-39J1LGJ30J; Tramadol Hydrochloride Enantiomer; 1S,2R-Tramadol HCl
EINECS	Contact for details

Quality Control

Our (1S,2R)-Tramadol Hydrochloride is manufactured under strict quality systems. Each batch is subjected to comprehensive analytical testing, including chiral purity assay, identification, and control of related substances and residual solvents, to ensure it meets stringent specifications for research and development use. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.5% (on anhydrous basis)
Chiral Purity (Enantiomeric Excess)	≥99.0%
Related Substances (HPLC)	Total impurities ≤1.0%
Water (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.