Description

Acetylcodeine Hydrochloride is a semi-synthetic opioid derivative of codeine, characterized by its high-purity hydrochloride salt form. This compound is of significant interest in pharmaceutical research and development, particularly for its potential as a controlled intermediate in the synthesis of specialized analgesics and for pharmacological studies. It serves the needs of advanced research laboratories, pharmaceutical development units, and chemical manufacturers focused on controlled substance synthesis and reference standard production.

Application

• Pharmaceutical Intermediate: A key controlled precursor in the research and development of novel opioid-based analgesic agents.
• Reference Standard: Used as a high-purity analytical standard in forensic, toxicology, and quality control laboratories for method validation and calibration.
• Pharmacological Research: Employed in preclinical studies to investigate the structure-activity relationships (SAR) of opioid receptor ligands and their metabolic pathways.
• Chemical Synthesis: Serves as a specialized building block for the synthesis of other acetylated opioid derivatives in controlled research environments.
• Regulatory Compliance Testing: Utilized by regulatory bodies and certified testing facilities to develop and verify detection methods for controlled substances.

Basic Information

Product Name	Acetylcodeine Hydrochloride
CAS No.	36418-36-7
Molecular Formula	C20H23NO4·HCl
Molecular Weight	377.86 g/mol
Synonyms	3-O-Acetylcodeine Hydrochloride; 6-Acetylcodeine Hydrochloride; Codeine-3-acetate Hydrochloride; Thebaine-3,6-diol 3-acetate 6-methyl ether hydrochloride; O3-Acetylcodeine HCl; Acetylcodeine HCl; 3-Acetylcodeine hydrochloride
EINECS	Contact for details

Quality Control

Our Acetylcodeine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets the stringent requirements for research and reference standard applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with specified analytical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Store in accordance with all local and international regulations for controlled substances.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.