Description

(5Alpha,6Alpha)-4,5-Epoxy-3-Methoxy-17-Methylmorphinan-6-Ol Hydrochloride is a high-purity pharmaceutical intermediate and reference standard of significant importance in research and development. This compound is critical for analytical and synthetic applications within the pharmaceutical industry, particularly in the study of opioid receptor activity and the development of related therapeutic agents. It is primarily required by pharmaceutical R&D laboratories, analytical testing facilities, and manufacturers of active pharmaceutical ingredients (APIs) for quality control and process development.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for the identification, assay, and impurity profiling of related active pharmaceutical ingredients (APIs) via HPLC, GC, or other analytical methods.
• Research & Development: Serves as a key intermediate or starting material in the synthesis of novel opioid analogs and other morphinan derivatives for pharmacological studies.
• Analytical Chemistry: Employed in method development and validation within quality control laboratories to ensure the accuracy and precision of analytical procedures.
• Impurity Standard: Acts as a known impurity or degradation product standard for stability testing and regulatory filing of pharmaceutical products.
• Biochemical Research: Utilized in in vitro studies to investigate binding affinity and functional activity at opioid receptors.
• Educational & Forensic Analysis: Used in academic settings for advanced chemistry education and in forensic laboratories for substance identification and characterization.

Basic Information

Item	Details
Product Name	(5Alpha,6Alpha)-4,5-Epoxy-3-Methoxy-17-Methylmorphinan-6-Ol Hydrochloride
CAS No.	36418-29-8
Molecular Formula	C18H23NO3·HCl
Molecular Weight	337.84 g/mol (Free base: 301.38 g/mol)
Synonyms	4,5α-Epoxy-3-methoxy-17-methylmorphinan-6α-ol hydrochloride; 6α-Hydroxy-4,5α-epoxy-3-methoxy-17-methylmorphinan hydrochloride; Noroxymorphone impurity; 6α-Noroxymorphone; 6-Hydroxy-4,5-epoxy-3-methoxy-17-methylmorphinan hydrochloride; (5α,6α)-4,5-Epoxy-3-methoxy-17-methylmorphinan-6-ol hydrochloride
EINECS	Contact for details

Quality Control

Our (5Alpha,6Alpha)-4,5-Epoxy-3-Methoxy-17-Methylmorphinan-6-Ol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity determination by HPLC, and control of specific impurities. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.