Description

Diethyl 3-Chloro-3-Oxopropylphosphonate is a versatile organophosphorus compound, specifically a β-ketophosphonate, that serves as a critical building block in organic synthesis. Its unique structure, featuring both a reactive chloro and carbonyl group adjacent to the phosphonate moiety, makes it an invaluable reagent for constructing complex molecular frameworks. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity intermediates for the development of active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of various drug candidates, including kinase inhibitors and other biologically active molecules.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and plant growth regulators.
• Material Science: Acts as a monomer or cross-linking agent in the development of specialty polymers and flame retardants.
• Organic Synthesis Reagent: Employed in Horner-Wadsworth-Emmons (HWE) olefination reactions to generate α,β-unsaturated carbonyl compounds.
• Ligand and Catalyst Preparation: Serves as a starting material for synthesizing novel phosphonate-based ligands for metal catalysis.
• Chemical Research: A valuable tool in academic and industrial R&D for exploring new synthetic methodologies and compound libraries.

Basic Information

Product Name	Diethyl 3-Chloro-3-Oxopropylphosphonate
CAS No.	36217-27-3
Molecular Formula	C7H14ClO4P
Molecular Weight	228.61 g/mol
Synonyms	3-Chloro-3-oxopropylphosphonic Acid Diethyl Ester; Diethyl (3-Chloro-3-oxopropyl)phosphonate; 3-Chloropropanoylphosphonate Diethyl Ester; Diethyl 3-Chloropropanoylphosphonate; (3-Chloro-3-oxopropyl)phosphonic Acid Diethyl Ester; β-Chloropropionylphosphonate Diethyl Ester; Diethyl β-Chloropropionylphosphonate; Diethyl P-(2-Chloroacetyl)phosphonate
EINECS	Contact for details

Quality Control

Our Diethyl 3-Chloro-3-Oxopropylphosphonate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chromatography (HPLC/GC) and spectroscopy (NMR, IR), to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We are committed to meeting the stringent requirements of cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Identification (NMR)	Conforms
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Chloride Content	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.