Description

(As,3S)-5-(4,5-Dimethoxy-2-Methyl-1-Naphtyl)-3,4-Dihydro-1,3β-Dimethyl-8-Methoxyisoquinolin-6-Ol is a high-purity, complex isoquinoline derivative of significant interest in advanced organic synthesis and pharmaceutical research. This compound serves as a critical chiral building block or intermediate for the development of novel therapeutic agents and fine chemicals. It is primarily sought after by research institutions, pharmaceutical development laboratories, and specialty chemical manufacturers engaged in the synthesis of complex alkaloids and other bioactive molecules.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the research and development of potential new drug candidates, particularly in central nervous system (CNS) or anti-cancer therapeutic areas.
• Organic Synthesis Building Block: Used in complex multi-step syntheses to construct intricate molecular architectures found in natural products and specialty chemicals.
• Biochemical Research: Employed as a reference standard or a probe in biochemical studies to investigate enzyme interactions or receptor binding mechanisms.
• Asymmetric Catalysis Studies: Serves as a substrate or ligand precursor in the development and testing of new asymmetric catalytic methodologies.
• Fine Chemical Production: Intermediate in the manufacture of high-value, low-volume specialty chemicals for advanced material science applications.

Basic Information

Product Name	(As,3S)-5-(4,5-Dimethoxy-2-Methyl-1-Naphtyl)-3,4-Dihydro-1,3β-Dimethyl-8-Methoxyisoquinolin-6-Ol
CAS No.	36209-87-7
Molecular Formula	C26H29NO5
Molecular Weight	435.52 g/mol
Synonyms	5-(4,5-Dimethoxy-2-methyl-1-naphthyl)-3,4-dihydro-1,3β-dimethyl-8-methoxyisoquinolin-6-ol; (1S,3S)-5-(4,5-Dimethoxy-2-methyl-1-naphthyl)-1,3-dimethyl-3,4-dihydro-8-methoxyisoquinolin-6-ol; 6-Hydroxy-5-(4,5-dimethoxy-2-methyl-1-naphthyl)-1,3-dimethyl-3,4-dihydroisoquinoline-8-methanol (stereoisomer); Isoquinolin-6-ol derivative; 36209-87-7; (As,3S)-isoquinoline intermediate
EINECS	Contact for details

Quality Control

Our (As,3S)-5-(4,5-Dimethoxy-2-Methyl-1-Naphtyl)-3,4-Dihydro-1,3β-Dimethyl-8-Methoxyisoquinolin-6-Ol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We support cGMP compliance for advanced intermediates and can tailor specifications to meet specific research or development project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) to minimize oxidation and ensure long-term stability. The container should be kept in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.