Description

Dimethyl Trimethylsilyl Phosphite is a versatile organosilicon reagent primarily used as a key intermediate in organic synthesis and pharmaceutical manufacturing. This compound is valued for its role as a silylating agent and phosphite donor, facilitating critical transformations in the production of complex molecules. It is essential for research and industrial applications in the pharmaceutical, agrochemical, and specialty chemical sectors where precise functional group protection and modification are required.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for nucleoside and nucleotide analogs.
• Silylating Agent: Used to introduce the trimethylsilyl (TMS) protecting group to alcohols, phenols, and other sensitive functional groups in multi-step organic syntheses.
• Phosphite Precursor: Serves as a precursor for generating other phosphite esters and phosphorus-containing ligands used in catalysis.
• Agrochemical Synthesis: Employed in the manufacture of certain pesticides and herbicides that require phosphorus-based functional groups.
• Polymer Modification: Used in the surface treatment and modification of polymers to impart specific chemical properties.
• Laboratory Reagent: A valuable reagent in research and development for exploring new synthetic methodologies and organophosphorus chemistry.

Basic Information

Product Name	Dimethyl Trimethylsilyl Phosphite
CAS No.	36198-87-5
Molecular Formula	C5H15O3PSi
Molecular Weight	182.24 g/mol
Synonyms	Dimethyl (Trimethylsilyl) Phosphite; Trimethylsilyl Dimethyl Phosphite; Phosphorous Acid, Dimethyl Trimethylsilyl Ester; (Dimethoxyphosphinyloxy)trimethylsilane; TMS-Dimethyl Phosphite; DMTP; CAS 36198-87-5
EINECS	Contact for details

Quality Control

Our Dimethyl Trimethylsilyl Phosphite is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. The product undergoes rigorous analytical testing, including GC, NMR, and titration methods, to verify identity, potency, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation from moisture and oxidation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~1.0 g/cm³
Refractive Index (n20D)	~1.410

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.