Description

4-Chloro-3-formyl-2-thiopheneboronic acid is a versatile and highly functionalized organoboron building block essential for modern synthetic chemistry. Its unique structure, featuring both a formyl and a boronic acid group on a chlorinated thiophene core, makes it a critical intermediate for constructing complex heterocyclic systems. This compound is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for applications in Suzuki-Miyaura cross-coupling reactions and further derivatization.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, leveraging the thiophene scaffold for enhanced biological activity.
• Material Science Research: Serves as a monomer or building block for creating conjugated polymers and organic electronic materials like organic light-emitting diodes (OLEDs) and semiconductors.
• Chemical Biology & Proteomics: Employed in the design and synthesis of molecular probes, enzyme inhibitors, and bioconjugation reagents due to its reactive functional groups.
• Ligand Synthesis for Catalysis: Utilized to prepare sophisticated bidentate or tridentate ligands for transition metal catalysis.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving diverse R&D projects.

Basic Information

Product Name	4-Chloro-3-formyl-2-thiopheneboronic Acid
CAS No.	36155-92-7
Molecular Formula	C5H4BClO3S
Molecular Weight	190.41 g/mol
Synonyms	(4-Chloro-3-formylthiophen-2-yl)boronic acid; 4-Chloro-3-formylthiophene-2-boronic acid; 2-Borono-4-chloro-3-formylthiophene; 4-Chloro-3-formyl-2-thienylboronic acid; 4-Chloro-3-formylthiophene-2-boronique acide (French); 4-Chloro-3-formyl-2-thiopheneboronsäure (German); 4-Chloro-3-formyl-2-thienyl-BA
EINECS	Contact for details

Quality Control

Our 4-Chloro-3-formyl-2-thiopheneboronic acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for demanding synthetic applications. We employ advanced analytical techniques including HPLC, NMR, and mass spectrometry for comprehensive characterization. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under inert atmosphere (argon/nitrogen) when opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.