Description

Ethyl 2-Amino-4-(4-Fluorophenyl)Thiophene-3-Carboxylate is a high-value pharmaceutical intermediate characterized by its thiophene core and fluorinated aromatic substituent. This compound matters for its critical role as a building block in the synthesis of advanced active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and inflammatory pathways. Pharmaceutical R&D departments and fine chemical manufacturers need this material for developing new drug candidates and scaling up production processes.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug molecules, especially in medicinal chemistry research.
• API Synthesis: Used in the manufacturing route for Active Pharmaceutical Ingredients (APIs) with thiophene-based structures.
• Chemical Research & Development: Serves as a versatile scaffold for constructing complex heterocyclic compounds in academic and industrial labs.
• Agrochemical Development: Potential application as an intermediate in the research and synthesis of new crop protection agents.
• Material Science: Exploration of its use in the development of organic electronic materials due to its conjugated thiophene system.

Basic Information

Product Name	Ethyl 2-Amino-4-(4-Fluorophenyl)Thiophene-3-Carboxylate
CAS No.	35978-33-7
Molecular Formula	C13H12FNO2S
Molecular Weight	265.30 g/mol
Synonyms	Ethyl 2-Amino-4-(p-fluorophenyl)thiophene-3-carboxylate; 2-Amino-4-(4-fluorophenyl)thiophene-3-carboxylic acid ethyl ester; 4-(4-Fluorophenyl)-2-aminothiophene-3-carboxylic acid ethyl ester; 3-Thiophenecarboxylic acid, 2-amino-4-(4-fluorophenyl)-, ethyl ester; Ethyl α-amino-4-(4-fluorophenyl)thiophene-3-carboxylate; 35978-33-7; AKOS BRN 0978
EINECS	Contact for details

Quality Control

Our Ethyl 2-Amino-4-(4-Fluorophenyl)Thiophene-3-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to verify identity, purity, and impurity profiles. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.