Description

3-Fluoro-D-(2-2H)Alanine is a deuterated and fluorinated analog of the amino acid alanine, serving as a sophisticated biochemical tool. This compound is valued for its dual isotopic labeling, which provides unique advantages in metabolic and pharmacokinetic studies by enhancing detection sensitivity and stability. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced drug discovery, metabolic pathway analysis, and proteomics research.

Application

• Pharmaceutical Research & Development: As a stable isotope-labeled building block for the synthesis of novel drug candidates, particularly in probing metabolic stability and bioavailability.
• Metabolic Pathway Tracing: Used in mass spectrometry (MS) and nuclear magnetic resonance (NMR) studies to track and quantify biochemical pathways in vivo and in vitro.
• Proteomics and Biomarker Discovery: Employed in quantitative proteomics for internal standardization and accurate protein quantification.
• Enzyme Mechanism Studies: Acts as a substrate or inhibitor analog to investigate enzyme kinetics and mechanisms involving alanine metabolism.
• Medical Imaging Agent Development: A potential precursor for developing Positron Emission Tomography (PET) tracers, leveraging the fluorine-18 isotope.
• Academic & Industrial Biochemistry: Serves as a critical reagent in fundamental research on amino acid transport, protein synthesis, and cell signaling.

Basic Information

Item	Details
Product Name	3-Fluoro-D-(2-2H)Alanine
CAS No.	35523-45-6
Molecular Formula	C₃H₄D₂FNO₂
Molecular Weight	123.09 g/mol
Synonyms	(2R)-2-Amino-3-fluoro-3,3-dideuteropropanoic acid; D-3-Fluoroalanine-2,2-d2; (R)-3-Fluoro-2,2-dideuteroalanine; 3-Fluoro-D-alanine-2,2-d2; 3-Fluoro-DL-alanine-2,2-d2 (mixture); 3-Fluoroalanine-d2; Fluorodeuteroalanine; Deuterated 3-Fluoro-D-alanine
EINECS	Contact for details

Quality Control

Every batch of 3-Fluoro-D-(2-2H)Alanine is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing including HPLC, NMR, and MS analysis to confirm identity, assay, and deuterium incorporation. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to ensure traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium, MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.