Description

Trimethyl-D8-Amine is a deuterium-labeled isotopologue of trimethylamine, where all nine hydrogen atoms are replaced by deuterium (D). This high isotopic purity makes it an essential internal standard and tracer in advanced analytical chemistry and metabolic research. It is primarily used by researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries who require precise quantification and pathway elucidation.

Application

• Analytical Chemistry: Serves as a critical internal standard for Gas Chromatography-Mass Spectrometry (GC-MS) and Liquid Chromatography-Mass Spectrometry (LC-MS) analysis of trimethylamine and related compounds, improving quantification accuracy.
• Pharmaceutical Research: Used as a stable-isotope labeled tracer in drug metabolism and pharmacokinetics (DMPK) studies to investigate metabolic pathways and bioavailability.
• Biochemical Studies: Employed in research on trimethylamine N-oxide (TMAO) pathways, gut microbiome metabolism, and related cardiovascular disease studies.
• Material Science: Acts as a precursor or labeling agent in the synthesis of deuterated polymers, liquid crystals, or other advanced materials where isotopic labeling modifies physical properties.
• NMR Spectroscopy: Useful as a deuterated solvent or shift reference in Nuclear Magnetic Resonance (NMR) experiments due to its distinct spectral properties.

Basic Information

Product Name	Trimethyl-D8-Amine
CAS No.	35434-71-0
Molecular Formula	C3D9N
Molecular Weight	68.17 g/mol
Synonyms	Perdeuterotrimethylamine; Trimethylamine-d9; N,N-Dimethylmethanamine-d9; TMA-d9; Deuterated Trimethylamine; (2H9)Trimethylamine; N(CD3)3; Methanamine, N,N-dimethyl-, d9-
EINECS	Contact for details

Quality Control

Our Trimethyl-D8-Amine is produced and handled under strict quality protocols to ensure high chemical and isotopic purity, essential for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as isotopic enrichment (Atom % D), chemical purity (by GC or NMR), and impurity profiles. We adhere to cGMP standards where applicable to support research and development requiring reliable, traceable materials.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile and gaseous nature under standard conditions, store in a cool, well-ventilated area, preferably under inert atmosphere or refrigeration as specified. Keep away from strong oxidizers and acids.

Specification

Item	Specification
Appearance	Colorless gas / compressed liquid
Identification (IR / NMR)	Conforms to structure
Isotopic Purity (Atom % D)	≥ 98% (or as specified)
Chemical Purity (GC)	≥ 99%
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.