Description

1,2,3,4-Tetrahydro-Cyclopenta[B]Indole-2-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate with a complex fused-ring structure. This compound is a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders. It is essential for research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, where its structural integrity and purity directly impact the efficacy and safety of the final drug product.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially for neurological and psychiatric applications.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the discovery of new bioactive molecules.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a core scaffold for constructing APIs with the tetrahydrocyclopentaindole moiety.
• Contract Manufacturing (CMO/CDMO): Supplied to contract research and manufacturing organizations for custom synthesis projects under GMP guidelines.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	1,2,3,4-Tetrahydro-Cyclopenta[B]Indole-2-Carboxylic Acid
CAS No.	35418-49-6
Molecular Formula	C₁₂H₁₁NO₂
Molecular Weight	201.22 g/mol
Synonyms	2-Carboxy-1,2,3,4-tetrahydrocyclopenta[b]indole; Cyclopenta[b]indole-2-carboxylic acid, 1,2,3,4-tetrahydro-; Tetrahydrocyclopentaindole-2-carboxylic acid; 1,2,3,4-Tetrahydrocyclopentaindole-2-carboxylic acid; 35418-49-6; TCPCA; THCPI-2-COOH
EINECS	Contact for details

Quality Control

Our 1,2,3,4-Tetrahydro-Cyclopenta[B]Indole-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.