Description

1-(5-Bromothien-2-Yl)-2,2,2-Trifluoroethanol is a high-value organobromine and organofluorine building block, distinguished by its reactive trifluoroethanol and bromothiophene functional groups. This compound is critical for introducing specific steric and electronic properties into advanced molecular architectures. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the bromothiophene moiety contributes to biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the synthesis of monomers and polymers for advanced materials, including liquid crystals and organic semiconductors.
• Fluorine Chemistry Building Block: Essential for introducing the trifluoroethanol group into molecules to modulate lipophilicity, metabolic stability, and binding affinity.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthesis projects and scale-up activities.

Basic Information

Product Name	1-(5-Bromothien-2-Yl)-2,2,2-Trifluoroethanol
CAS No.	35304-69-9
Molecular Formula	C6H4BrF3OS
Molecular Weight	261.06 g/mol
Synonyms	2,2,2-Trifluoro-1-(5-bromothiophen-2-yl)ethanol; 1-(5-Bromo-2-thienyl)-2,2,2-trifluoroethanol; 5-Bromo-2-(2,2,2-trifluoro-1-hydroxyethyl)thiophene; α-(Trifluoromethyl)-5-bromothiophene-2-methanol; (5-Bromothiophen-2-yl)(trifluoromethyl)methanol; 35304-69-9; 2-(5-Bromothiophen-2-yl)-1,1,1-trifluoro-2-propanol (common misnomer)
EINECS	Contact for details

Quality Control

Every batch of 1-(5-Bromothien-2-Yl)-2,2,2-Trifluoroethanol is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.