Description

(S)-(+)-1,1'-Binaphthyl-2,2'-Diyl Hydrogenphosphate is a high-purity, chiral organophosphoric acid derivative, widely recognized as a versatile catalyst and resolving agent. Its primary value lies in its ability to induce enantioselectivity in a broad range of organic transformations, making it indispensable for the synthesis of optically active compounds. This product is essential for research and production in the pharmaceutical, agrochemical, and fine chemical industries, where precise stereochemical control is critical. The CAS number for this compound is 35193-64-7.

Application

• Asymmetric Organocatalysis: Serving as a highly effective Brønsted acid catalyst for enantioselective reactions such as Mannich, Friedel-Crafts, and transfer hydrogenation.
• Chiral Resolution: Utilized as a resolving agent for the separation of racemic mixtures of amines, amino alcohols, and other basic compounds.
• Pharmaceutical Intermediate Synthesis: A key chiral auxiliary in the production of active pharmaceutical ingredients (APIs) requiring specific enantiomeric purity.
• Ligand Precursor: Acts as a precursor for the synthesis of chiral phosphoric acid-derived ligands used in metal-catalyzed asymmetric synthesis.
• Material Science Research: Employed in the development of chiral stationary phases (CSPs) for HPLC and in the creation of chiral molecular recognition systems.
• Agrochemical Development: Used in the research and synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.

Basic Information

Product Name	(S)-(+)-1,1'-Binaphthyl-2,2'-Diyl Hydrogenphosphate
CAS No.	35193-64-7
Molecular Formula	C₂₀H₁₃O₄P
Molecular Weight	348.29 g/mol
Synonyms	(S)-1,1'-Bi-2-naphthol Hydrogen Phosphate; (S)-BINOL Phosphoric Acid; (S)-VAPOL Phosphoric Acid; (S)-(+)-1,1'-Binaphthyl-2,2'-diyl Dihydrogen Phosphate; (S)-1,1'-Binaphthyl-2,2'-diyl Acid Phosphate; (S)-BINAP Acid; (S)-BINOL Monophosphate; (S)-H8-BINOL Phosphoric Acid (for hydrogenated derivative).
EINECS	Contact for details

Quality Control

Our (S)-(+)-1,1'-Binaphthyl-2,2'-Diyl Hydrogenphosphate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is subjected to rigorous analytical testing, including HPLC for chiral purity and NMR for structural confirmation. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific rotation is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect performance. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Specific Rotation [α]²⁰D	+220° to +235° (c=1 in THF)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.