Description

1-[2-[2-(2,5-Dihydro-3-Methyl-2,5-Dioxo-1H-Pyrrol-1-Yl)Ethoxy]Ethyl]-5,5-Diethylbarbituric Acid is a specialized organic compound that serves as a key intermediate in advanced pharmaceutical synthesis. Its molecular architecture, combining a barbituric acid core with a reactive maleimide-like moiety, makes it a valuable building block for creating complex, bioactive molecules. This high-purity intermediate is essential for research and development chemists in the pharmaceutical and fine chemical industries, particularly for applications in medicinal chemistry and targeted drug discovery.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel barbiturate-derived active pharmaceutical ingredients (APIs) and prodrugs.
• Medicinal Chemistry Research: Used in the design and development of new chemical entities (NCEs) for central nervous system (CNS) and neurological disorder research.
• Bioconjugation & Linker Chemistry: The reactive pyrrolidine-2,5-dione (maleimide) group enables its use as a linker for protein-drug conjugates or antibody-drug conjugates (ADCs).
• Fine Chemical Synthesis: Employed in the multi-step synthesis of complex heterocyclic compounds for agrochemical and material science applications.
• Polymer Modification: Can be used to introduce functional barbiturate groups into polymer chains for specialty material development.
• Analytical Reference Standard: Serves as a high-purity standard for quality control and analytical method development in pharmaceutical manufacturing.

Basic Information

Product Name	1-[2-[2-(2,5-Dihydro-3-Methyl-2,5-Dioxo-1H-Pyrrol-1-Yl)Ethoxy]Ethyl]-5,5-Diethylbarbituric Acid
CAS No.	35189-15-2
Molecular Formula	C₁₇H₂₃N₃O₆
Molecular Weight	365.38 g/mol
Synonyms	5,5-Diethyl-1-[2-[2-(3-methyl-2,5-dioxo-1-pyrrolidinyl)ethoxy]ethyl]barbituric Acid; 1-[2-[2-(3-Methyl-2,5-dioxo-1-pyrrolidinyl)ethoxy]ethyl]-5,5-diethyl-2,4,6(1H,3H,5H)-pyrimidinetrione; 5,5-Diethyl-1-[2-[2-(3-methylmaleimido)ethoxy]ethyl]barbituric Acid; N-(2-(2-(5,5-Diethyl-2,4,6-trioxo-1,3-diazinan-1-yl)ethoxy)ethyl)-3-methylmaleimide; Barbituric Acid Derivative 35189-15-2
EINECS	Contact for details

Quality Control

Our 1-[2-[2-(2,5-Dihydro-3-Methyl-2,5-Dioxo-1H-Pyrrol-1-Yl)Ethoxy]Ethyl]-5,5-Diethylbarbituric Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide comprehensive Certificates of Analysis (COA) to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.